Neurotoxin that destroys catecholaminergic terminals.Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels. Induces apoptosis in PC-12 cells.\xa0Destroys\xa0nigral dopaminergic neurons and their striatal terminals\xa0in rat models of
Storage Temp
Store at -20°C,Argon charged
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Ice chest + Ice pads
Note
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Product Description
Solutions should be freshly prepared and protected from exposure to light. 6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals.
product description：
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.
1.Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba. (2023) Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1869 (166814). [PMID:37495085][10.1016/j.bbadis.2023.166814]
2.Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao. (2023) Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (1):(512–521). [PMID:36562659][10.1021/acs.jafc.2c06630]
3.Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen. (2022) Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease. JOURNAL OF PROTEOME RESEARCH, 21 (9):(2114–2123). [PMID:35959672][10.1021/acs.jproteome.2c00149]
References
1.Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba. (2023) Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1869 (166814). [PMID:37495085][10.1016/j.bbadis.2023.166814]
2.Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao. (2023) Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (1):(512–521). [PMID:36562659][10.1021/acs.jafc.2c06630]
3.Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen. (2022) Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease. JOURNAL OF PROTEOME RESEARCH, 21 (9):(2114–2123). [PMID:35959672][10.1021/acs.jproteome.2c00149]
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B2311660