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H425227-1ml

1ml

Available within 4-8 weeks(?)

$69.90

Basic Description

Synonyms	6-Hydroxydopamine hydrobromide \| 636-00-0 \| Oxidopamine hydrobromide \| Oxidopamine (hydrobromide) \| 6-hydroxydopamine hbr \| 6-OHDA \| 2,4,5-Trihydroxyphenethylamine hydrobromide \| 5-(2-aminoethyl)benzene-1,2,4-triol hydrobromide \| 6-OHDA HBr \| MFCD00012894 \| TWC1D4W0WB \| 2-(2,4
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Neurotoxin that destroys catecholaminergic terminals.Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels. Induces apoptosis in PC-12 cells.\xa0Destroys\xa0nigral dopaminergic neurons and their striatal terminals\xa0in rat models of
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Solutions should be freshly prepared and protected from exposure to light. 6-Hydroxydopamine hydrobromide is a neurotoxin which destroys catecholaminergic terminals. product description： 6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson's disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells.

Associated Targets(Human)

ERG Tbio Transcriptional regulator ERG (0 Activities)

Discover Target: ERG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EYA2 Tbio Eyes absent homolog 2 (0 Activities)

Discover Target: EYA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 (0 Activities)

Discover Target: CBX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin (0 Activities)

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLH Tchem DNA polymerase eta (0 Activities)

Discover Target: POLH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (0 Activities)

Discover Target: RAPGEF3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (0 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor (0 Activities)

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (0 Activities)

Discover Target: FEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic (0 Activities)

Discover Target: TXNRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WRN Tbio Werner syndrome ATP-dependent helicase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (0 Activities)

Discover Target: PIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota (0 Activities)

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 (0 Activities)

Discover Target: PLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 (0 Activities)

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (0 Activities)

Discover Target: G6PD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KPNB1 Tbio Importin subunit beta-1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLS Tchem Glutaminase kidney isoform, mitochondrial (0 Activities)

Discover Target: GLS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A (0 Activities)

Discover Target: KDM4A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLH Tchem DNA polymerase eta (21678 Activities)

Discover Target: POLH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

G6PD Tchem Glucose-6-phosphate 1-dehydrogenase (778 Activities)

Discover Target: G6PD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERG Tbio Transcriptional regulator ERG (5589 Activities)

Discover Target: ERG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EYA2 Tbio Eyes absent homolog 2 (5884 Activities)

Discover Target: EYA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

Discover Target: RAPGEF3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

WRN Tbio Werner syndrome ATP-dependent helicase (8824 Activities)

Discover Target: WRN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)

Discover Target: KPNB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

G6PD-6PGL Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (1761 Activities)

Discover Target: G6PD-6PGL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide
INCHI	InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChi Key	MLACDGUOKDOLGC-UHFFFAOYSA-N
Canonical SMILES	C1=C(C(=CC(=C1O)O)O)CCN.Br
Isomeric SMILES	C1=C(C(=CC(=C1O)O)O)CCN.Br
WGK Germany	3
RTECS	DC4600000
PubChem CID	176170
Molecular Weight	250.09
Beilstein	3713280

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Light&Moisture sensitive
Melt Point(°C)	216-220°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P405:Store locked up. P501:Dispose of contents/container to ... P312:Call a POISON CENTER or doctor/... if you feel unwell. P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
WGK Germany	3
RTECS	DC4600000

Citations of This Product

1. Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba. (2023) Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1869 (166814). [PMID:37495085]
2. Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao. (2023) Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (1): (512–521). [PMID:36562659]
3. Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen. (2022) Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease. JOURNAL OF PROTEOME RESEARCH, 21 (9): (2114–2123). [PMID:35959672]

References

1. Xue-Yun Chen, Si-Ning Feng, Yin Bao, Yu-Xin Zhou, Fang Ba. (2023) Identification of Clec7a as the therapeutic target of rTMS in alleviating Parkinson's disease: targeting neuroinflammation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1869 (166814). [PMID:37495085]
2. Yi-Kao Hu, Yi-Ming Liu, Xiao-Lin Bai, Chao Ma, Xun Liao. (2023) Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (1): (512–521). [PMID:36562659]
3. Feifei Zhu, Han Chen, Jinying Han, Weiwei Zhou, Qi Tang, Qian Yu, Shangshang Ma, Xiaoyong Liu, Shuhao Huo, Keping Chen. (2022) Proteomic and Targeted Metabolomic Studies on a Silkworm Model of Parkinson’s Disease. JOURNAL OF PROTEOME RESEARCH, 21 (9): (2114–2123). [PMID:35959672]

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6-Hydroxydopamine hydrobromide - 10mM in DMSO, high purity , CAS No.636-00-0