Grouped product items

SKU

Size

Availability

Price

Qty

H135753-5mg

5mg

Available within 8-12 weeks(?)

$36.90

H135753-10mg

10mg

Available within 8-12 weeks(?)

$54.90

H135753-25mg

25mg

Available within 8-12 weeks(?)

$94.90

H135753-50mg

50mg

Available within 8-12 weeks(?)

$113.90

H135753-100mg

100mg

Available within 8-12 weeks(?)

$179.90

Basic Description

Synonyms	Oxidopamine (hydrochloride) \| 2,4,5-Trihydroxyphenethylamine hydrochloride \| Oxidopamine hydrochloride \| 6-OHDA
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Neurotoxin that destroys catecholaminergic terminals.
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Product Description	6-Hydroxydopamine hydrochloride is a selective catecholaminergic neurotoxin. 6-Hydroxydopamine hydrochloride depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease. A selective catecholaminergic neurotoxin.

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

Discover Target: ALOX15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

Discover Target: PIN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

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ACHN (49357 Activities)

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CAKI-1 (44928 Activities)

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CCRF-CEM (65223 Activities)

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COLO 205 (50209 Activities)

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DU-145 (51482 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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KM12 (47707 Activities)

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M14 (47487 Activities)

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MCF7 (126967 Activities)

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MOLT-4 (49676 Activities)

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OVCAR-3 (48710 Activities)

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OVCAR-5 (45555 Activities)

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OVCAR-8 (47708 Activities)

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PC-3 (62116 Activities)

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RPMI-8226 (44974 Activities)

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RXF 393 (41971 Activities)

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SF-295 (48000 Activities)

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SK-MEL-2 (46422 Activities)

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SK-MEL-28 (48833 Activities)

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SK-MEL-5 (47095 Activities)

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SK-OV-3 (52876 Activities)

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SN12C (47755 Activities)

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SNB-19 (46794 Activities)

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TK-10 (45540 Activities)

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UACC-257 (46019 Activities)

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UACC-62 (47335 Activities)

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UO-31 (46270 Activities)

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786-0 (47912 Activities)

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A549 (127892 Activities)

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NCI/ADR-RES (33767 Activities)

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T47D (39041 Activities)

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EKVX (44102 Activities)

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NCI-H322M (45589 Activities)

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HCC 2998 (41480 Activities)

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HCT-116 (91556 Activities)

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HEK293 (82097 Activities)

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NCI-H460 (60772 Activities)

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SF-268 (49410 Activities)

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IGROV-1 (47897 Activities)

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HOP-62 (47048 Activities)

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MDA-MB-435 (38290 Activities)

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MDA-N (28205 Activities)

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Malme-3M (44254 Activities)

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MDA-MB-231 (73002 Activities)

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Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

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Plasmodium falciparum (966862 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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ddn Putative uncharacterized protein (49 Activities)

Discover Target: ddn

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Phaseolus vulgaris (518 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

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Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

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groL GroEL/GroES (1042 Activities)

Discover Target: groL

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SARS-CoV-2 (38078 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-(2-aminoethyl)benzene-1,2,4-triol;hydrochloride
INCHI	InChI=1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
InChi Key	QLMRJHFAGVFUAC-UHFFFAOYSA-N
Canonical SMILES	C1=C(C(=CC(=C1O)O)O)CCN.Cl
Isomeric SMILES	C1=C(C(=CC(=C1O)O)O)CCN.Cl
WGK Germany	3
RTECS	DC4650000
PubChem CID	160157
Molecular Weight	205.64
Beilstein	4274007

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
E2421155	Certificate of Analysis	May 25, 2024	H135753
E2421156	Certificate of Analysis	May 25, 2024	H135753
E2421157	Certificate of Analysis	May 25, 2024	H135753
A2424125	Certificate of Analysis	Jan 27, 2024	H135753
A2424129	Certificate of Analysis	Jan 27, 2024	H135753
A2424130	Certificate of Analysis	Jan 27, 2024	H135753
A2424133	Certificate of Analysis	Jan 27, 2024	H135753
A2424134	Certificate of Analysis	Jan 27, 2024	H135753
A2424138	Certificate of Analysis	Jan 27, 2024	H135753
A2424140	Certificate of Analysis	Jan 27, 2024	H135753
A2424128	Certificate of Analysis	Jan 26, 2024	H135753
A2424139	Certificate of Analysis	Jan 26, 2024	H135753

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Chemical and Physical Properties

Solubility	Soluble in water (>50 mg/ml).
Sensitivity	Hygroscopic；Light sensitive
Melt Point(°C)	232-233 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	DC4650000

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] [10.1016/j.jconrel.2023.07.003]
2. Yanlin Chen, Gang Zheng, Yujie Bian, Haiwei Ma, Chenqiang Jin, Zhichao Hu, Haohan Su, Xinli Hu, Zhiyong Qian, Liyan Shen, Wenfei Ni. (2022) Hybrid multilayer coating as the psoralen delivery vehicle promoting bone regeneration on titanium mesh scaffolds in a Posterolateral Spinal Fusion model. Applied Materials Today, 28 (101530). [PMID:] [10.1016/j.apmt.2022.101530]

References

1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo. (2023) Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels. JOURNAL OF CONTROLLED RELEASE, 360 (433). [PMID:37422124] [10.1016/j.jconrel.2023.07.003]
2. Yanlin Chen, Gang Zheng, Yujie Bian, Haiwei Ma, Chenqiang Jin, Zhichao Hu, Haohan Su, Xinli Hu, Zhiyong Qian, Liyan Shen, Wenfei Ni. (2022) Hybrid multilayer coating as the psoralen delivery vehicle promoting bone regeneration on titanium mesh scaffolds in a Posterolateral Spinal Fusion model. Applied Materials Today, 28 (101530). [PMID:] [10.1016/j.apmt.2022.101530]

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6-HydroxyDopamineHydrochloride - 97%, high purity , CAS No.28094-15-7

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
H135753-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$36.90
H135753-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$54.90
H135753-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$94.90
H135753-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$113.90
H135753-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90