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SKU | Size | Availability | Price | Qty |
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O426176-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $91.90 |
GPR Agonists
Specifications & Purity | Moligand™, 10mM in DMSO |
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Biochemical and Physiological Mechanisms | 6-OAU (GTPL5846, 6-n-octylaminouracil) is a surrogate agonist of G protein-coupled receptor 84 (GPR84) that activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in the PI assay. 6-OAU (GTPL5846, 6-n-octylaminouracil) i |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Information 6-OAU 6-OAU (GTPL5846, 6-n-octylaminouracil) is a surrogate agonist of G protein-coupled receptor 84 (GPR84) that activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in the PI assay. 6-OAU (GTPL5846, 6-n-octylaminouracil) increases [35S]GTPγS incorporated in Sf9 cell membranes expressing human GPR84-Gαi fusion protein with EC50 of 512 nM. Targets hGPR84 (in the PI assay); human GPR84-Gαi fusion protein (Cell-free assay) 105 nM(EC50); 512 nM(EC50) |
ALogP | 2.354 |
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HBD Count | 3 |
Rotatable Bond | 8 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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G-protein coupled receptor 84 negative allosteric modulator | NEGATIVE ALLOSTERIC MODULATOR | ALA3714079 | G-protein coupled receptor 84 | SINGLE PROTEIN | Homo sapiens | ||
G-protein coupled receptor 84 antagonist | ANTAGONIST | ALA3714079 | G-protein coupled receptor 84 | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
IUPAC Name | 6-(octylamino)-1H-pyrimidine-2,4-dione |
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INCHI | InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17) |
InChi Key | PFSWASUQURIOOR-UHFFFAOYSA-N |
Canonical SMILES | CCCCCCCCNC1=CC(=O)NC(=O)N1 |
Isomeric SMILES | CCCCCCCCNC1=CC(=O)NC(=O)N1 |
PubChem CID | 10354234 |
Molecular Weight | 239.31 |
DMSO(mg / mL) Max Solubility | 35 |
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DMSO(mM) Max Solubility | 146.25381304584 |
Water(mg / mL) Max Solubility | <1 |