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6-OAU - 10mM in DMSO, high purity , CAS No.83797-69-7

Item Number
O426176
Grouped product items
SKUSizeAvailabilityPrice Qty
O426176-1ml
1ml
Available within 8-12 weeks(?)
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$91.90

GPR Agonists

Basic Description

Specifications & PurityMoligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms6-OAU (GTPL5846, 6-n-octylaminouracil) is a surrogate agonist of G protein-coupled receptor 84 (GPR84) that activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in the PI assay. 6-OAU (GTPL5846, 6-n-octylaminouracil) i
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

Information

6-OAU 6-OAU (GTPL5846, 6-n-octylaminouracil) is a surrogate agonist of G protein-coupled receptor 84 (GPR84) that activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with EC50 of 105 nM in the PI assay. 6-OAU (GTPL5846, 6-n-octylaminouracil) increases [35S]GTPγS incorporated in Sf9 cell membranes expressing human GPR84-Gαi fusion protein with EC50 of 512 nM.

Targets

hGPR84 (in the PI assay); human GPR84-Gαi fusion protein (Cell-free assay) 105 nM(EC50); 512 nM(EC50)

Product Properties

ALogP2.354
HBD Count3
Rotatable Bond8

Associated Targets(Human)

GPR84 Tchem G-protein coupled receptor 84 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
G-protein coupled receptor 84 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORALA3714079G-protein coupled receptor 84SINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


G-protein coupled receptor 84 antagonistANTAGONISTALA3714079G-protein coupled receptor 84SINGLE PROTEINHomo sapiens

PubMed: [1]


Names and Identifiers

IUPAC Name 6-(octylamino)-1H-pyrimidine-2,4-dione
INCHI InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17)
InChi Key PFSWASUQURIOOR-UHFFFAOYSA-N
Canonical SMILES CCCCCCCCNC1=CC(=O)NC(=O)N1
Isomeric SMILES CCCCCCCCNC1=CC(=O)NC(=O)N1
PubChem CID 10354234
Molecular Weight 239.31

Certificates

C of A & Other Certificates

Chemical and Physical Properties

DMSO(mg / mL) Max Solubility35
DMSO(mM) Max Solubility146.25381304584
Water(mg / mL) Max Solubility<1

Related Documents

Solution Calculators