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6-(p-Tolyl)-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-4-amine , CAS No.P609381, Inhibitor of epidermal growth factor receptor
Basic Description
| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | INHIBITOR |
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| Mechanism of action | Inhibitor of epidermal growth factor receptor |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 6-(p-Tolyl)-N-(3,4,5-trimethoxyphenyl)thieno[3,2-d]pyrimidin-4-amine |
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| INCHI | InChI=1S/C22H21N3O3S/c1-13-5-7-14(8-6-13)19-11-16-21(29-19)22(24-12-23-16)25-15-9-17(26-2)20(28-4)18(10-15)27-3/h5-12H,1-4H3,(H,23,24,25) |
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| InChi Key | IXKCNJIWRNIRNO-UHFFFAOYSA-N |
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| Canonical SMILES | COc1cc(cc(c1OC)OC)Nc1ncnc2c1sc(c2)c1ccc(cc1)C |
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| Isomeric SMILES | CC1=CC=C(C=C1)C2=CC3=C(S2)C(=NC=N3)NC4=CC(=C(C(=C4)OC)OC)OC |
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| PubChem CID | 137321167 |
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References
| 1. Romagnoli R, Prencipe F, Oliva P, Baraldi S, Baraldi PG, Schiaffino Ortega S, Chayah M, Kimatrai Salvador M, Lopez-Cara LC, Brancale A et al.. (2019) Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2- d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors.. J Med Chem, 62 (3): (1274-1290). [PMID:30633509] [10.1021/op500134e] |
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