6-Propyl-2-thiouracil - 98%, high purity , CAS No.51-52-5

Item Number

P106338

• Synonyms: propylthiouracil | 51-52-5 | 6-Propyl-2-thiouracil | Propacil | Prothiurone | Prothyran | Procasil | Propycil | 2-Mercapto-6-propylpyrimidin-4-ol | Prothiucil | Protiural | Thiuragyl | 6-N-Propylthiouracil | Propythiouracil | Prothycil | Propilthiouracil | Propyl-Thiorist | Propyl-Thyraci
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Non-competitive type I iodothyronine deiodinase inhibitor (IC 50 = 0.2 μM). Thyroperoxidase inhibitor. Inhibits 5'-deiodinase peripherally. Reduces the production of thyroxine in vivo. Centrally active.
• Shipped In: Normal
• Grade: Moligand™
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

6-PTU is a thiolated uracil derivativewhich has been shown to acts as an antihyperthyroid agent. 6-Propyl-2-thiouracil is known to inhibit the deiodination of thyroxine to triiodothyronine via deiodinase, iodothyronine, type I (DIO1).
It is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.