| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T421837-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $149.90 |
Antimetabolite. Guanine analog.
| Synonyms | thioguanine | 6-Thioguanine | 154-42-7 | Tioguanine | 2-Amino-6-mercaptopurine | 6-Mercaptoguanine | Tabloid | 2-Amino-6-purinethiol | Tioguanin | Lanvis | 2-Amino 6MP | 2-Aminopurin-6-thiol | 2-Aminopurine-6-thiol | 2-Aminopurine-6(1H)-thione | 2-Amino-9H-purine-6-thiol | Wellcome U3 |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides. Ribosylated and phosphorylate |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | 6-Thioguanine is a chemotherapy drug that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein. |
| ALogP | -0.1 |
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| IUPAC Name | 2-amino-3,7-dihydropurine-6-thione |
|---|---|
| INCHI | InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) |
| InChi Key | WYWHKKSPHMUBEB-UHFFFAOYSA-N |
| Canonical SMILES | C1=NC2=C(N1)C(=S)N=C(N2)N |
| Isomeric SMILES | C1=NC2=C(N1)C(=S)N=C(N2)N |
| WGK Germany | 3 |
| RTECS | UP0740000 |
| PubChem CID | 2723601 |
| UN Number | 2811 |
| Packing Group | I |
| Molecular Weight | 167.19 |
| Beilstein | 157765 |
| Reaxy-Rn | 1074099 |
Enter Lot Number to search for COA:
| Melt Point(°C) | 360°C |
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| Pictogram(s) | GHS06, GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H301:Toxic if swallowed H341:Suspected of causing genetic defects |
| Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. |
| WGK Germany | 3 |
| RTECS | UP0740000 |
| Reaxy-Rn | 1074099 |
| Class | 6.1 |
| Merck Index | 9337 |
| 1. Jia Wang, Deyue Yan, Wei Huang. (2022) A fluorescence zinc metal-organic framework for the effective detection of Fe3+ and Fe2+ in water. INORGANIC CHEMISTRY COMMUNICATIONS, 138 (109282). [PMID:] |
| 2. Yu Zhang, Xin Xu, Bing Yan. (2022) A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting. Journal of Materials Chemistry C, 10 (9): (3576-3584). [PMID:] |
| 3. Bingyong Lin, Yueliang Wang, Yuanyuan Yao, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo. (2021) Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix. ANALYTICAL CHEMISTRY, 93 (49): (16727–16733). [PMID:34851090] |
| 1. Jia Wang, Deyue Yan, Wei Huang. (2022) A fluorescence zinc metal-organic framework for the effective detection of Fe3+ and Fe2+ in water. INORGANIC CHEMISTRY COMMUNICATIONS, 138 (109282). [PMID:] |
| 2. Yu Zhang, Xin Xu, Bing Yan. (2022) A multicolor-switchable fluorescent lanthanide MOFs triggered by anti-cancer drugs: multifunctional platform for anti-cancer drug sensing and information anticounterfeiting. Journal of Materials Chemistry C, 10 (9): (3576-3584). [PMID:] |
| 3. Bingyong Lin, Yueliang Wang, Yuanyuan Yao, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo. (2021) Oil-Free Gold Nanobipyramid@Ag Microgels as a Functional SERS Substrate for Direct Detection of Small Molecules in a Complex Sample Matrix. ANALYTICAL CHEMISTRY, 93 (49): (16727–16733). [PMID:34851090] |
