680C91 - 98%, high purity , CAS No.163239-22-3

  • ≥98%
Item Number
C274720
Grouped product items
SKUSizeAvailabilityPrice Qty
C274720-5mg
5mg
In stock
$109.90
C274720-25mg
25mg
In stock
$334.90
C274720-100mg
100mg
In stock
$1,203.90

Potent, selective, substrate competitive tryptophan 2,3-dioxygenase inhibitor

Basic Description

SynonymsMS-23388 | 680C91 | s8997 | 1H-Indole, 6-fluoro-3-[2-(3-pyridinyl)ethenyl]-, (E)-; 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole | 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole | 6-fluoro-3-[(E)-2-(pyridin-3-yl)vinyl]-1H-indole | (e)-6-fluoro-3-
Specifications & Purity≥98%
Biochemical and Physiological MechanismsPotent, selective, substrate competitive tryptophan 2,3-dioxygenase inhibitor (K i = 51 nM). Inhibits tryptophan catabolism. Increases brain tryptophan and serotonin levels in vivo. 680C91 is a potent inhibitor of tryptophan 2,3-dioxygenase (TDO), which d
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

TDO2 Tchem Tryptophan 2,3-dioxygenase (9 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Tdo2 Tryptophan 2,3-dioxygenase (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P815 (244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ido1 Indoleamine 2,3-dioxygenase 1 (313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 6-fluoro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indole
INCHI InChI=1S/C15H11FN2/c16-13-5-6-14-12(10-18-15(14)8-13)4-3-11-2-1-7-17-9-11/h1-10,18H/b4-3+
InChi Key YBSDQTBCNYWBMX-ONEGZZNKSA-N
Canonical SMILES C1=CC(=CN=C1)C=CC2=CNC3=C2C=CC(=C3)F
Isomeric SMILES C1=CC(=CN=C1)/C=C/C2=CNC3=C2C=CC(=C3)F
PubChem CID 10014426
Molecular Weight 238.26

Certificates

Certificate of Analysis(COA)

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3 results found

Lot NumberCertificate TypeDateItem
H2223484Certificate of AnalysisJun 07, 2023 C274720
H2223485Certificate of AnalysisJun 07, 2023 C274720
H2223486Certificate of AnalysisJun 07, 2023 C274720

Chemical and Physical Properties

SolubilitySoluble in ethanol to 50 mM and in DMSO to 100 mM

Safety and Hazards(GHS)

Pictogram(s) GHS05
Signal Danger
Hazard Statements

H318:Causes serious eye damage

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

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