7,8-Dihydroxyflavone Hydrate - ≥98.0%(HPLC), high purity , CAS No.38183-03-8

Item Number

D137213

• Synonyms: NINDS_000371 | 7,8-dihydroxy-2-phenylchromen-4-one | MFCD00006836 | 7,8-Dihydroxy-2-phenyl-4-benzopyrone | 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl- | HMS3886D10 | KBio2_006703 | 5-18-04-00079 (Beilstein Handbook Reference) | BRD-K49535716-001-03-2 |
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: 7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity
• Storage Temp: Store at 2-8°C,Argon charged
• Shipped In: Wet ice
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

7,8-Dihydroxyflavone hydrate is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor with a Kd value of 320 nM. It also inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro.
7,8-Dihydroxyflavone (7,8-DHF), a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension. 7,8-Dihydroxyflavone may be used to study its effects on scopolamine induced Alzheimer-like pathologic dysfunction.