7,8-Dihydroxyflavone Hydrate - 10mM in DMSO, high purity , CAS No.38183-03-8

Item Number

D423768

• Synonyms: 7,8-dihydroxyflavone | 38183-03-8 | 7,8-dihydroxy-2-phenyl-4H-chromen-4-one | 7,8-DHF | 7,8-Dihydroxyflavone hydrate | 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-phenyl- | 7,8-Dihydroxy-flavone | 7,8-Dihydroxy-2-phenyl-chromen-4-one | 7,8-dihydroxy-2-phenylchromen-4-one | 7,8-
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: 7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

7,8-Dihydroxyflavone hydrate is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor with a Kd value of 320 nM. It also inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro.
7,8-Dihydroxyflavone (7,8-DHF), a selective tyrosine kinase receptor B (neurotrophic factor/tropomyosin-receptor-kinase B; TrkB) agonist, may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving neuroprotection, memory, vasorelaxation and hypertension. 7,8-Dihydroxyflavone may be used to study its effects on scopolamine induced Alzheimer-like pathologic dysfunction.