7-Cl-O-Nec1 - ≥98%, high purity , CAS No.852391-15-2, Inhibitor of receptor interacting serine/threonine kinase 1

Item Number
C275378
Grouped product items
SKUSizeAvailabilityPrice Qty
C275378-5mg
5mg
In stock
$132.90
C275378-25mg
25mg
In stock
$598.90
C275378-50mg
50mg
In stock
$662.90
C275378-100mg
100mg
In stock
$1,193.90
C275378-250mg
250mg
In stock
$2,685.90

Potent, selective, metabolically stable RIP1 inhibitor

Basic Description

Specifications & PurityMoligand™, ≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of receptor interacting serine/threonine kinase 1
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Jurkat (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1548 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488190978
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488190978
IUPAC Name 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
INCHI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
InChi Key WIKGAEMMNQTUGL-UHFFFAOYSA-N
Canonical SMILES CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
Isomeric SMILES CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
PubChem CID 643953
NSC Number 745841
Molecular Weight 277.7

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
D2325785Certificate of AnalysisFeb 20, 2024 C275378
D2325797Certificate of AnalysisFeb 20, 2024 C275378
D2325798Certificate of AnalysisFeb 20, 2024 C275378
D2325807Certificate of AnalysisFeb 20, 2024 C275378
D2325808Certificate of AnalysisFeb 20, 2024 C275378
D2325781Certificate of AnalysisJan 31, 2024 C275378
D2325803Certificate of AnalysisJan 31, 2024 C275378
D2325820Certificate of AnalysisJan 31, 2024 C275378
D2325841Certificate of AnalysisJan 31, 2024 C275378
D2325844Certificate of AnalysisJan 31, 2024 C275378

Chemical and Physical Properties

SolubilitySoluble in DMSO to 90 mM

Related Documents

References

1. Muendlein HI et al..  (2020)  Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation..  Cell Rep,  30  (3): (699-713.e4).  [PMID:31968247]
2. Wandel MP et al..  (2020)  Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms..  Nat Immunol,  21  (8): (880-891).  [PMID:32541830]
3. Henning Y et al..  (2022)  Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction..  Cell Death Dis,  13  (7): (662).  [PMID:35906211]
4. Yambire KF et al..  (2019)  Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo..  Elife,    [PMID:31793879]
5. Egorshina AY et al..  (2022)  Necroptosis as a Novel Facet of Mitotic Catastrophe..  Int J Mol Sci,  23  (7):   [PMID:35409093]
6. Peek SL et al..  (2022)  p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2..  iScience,  25  (2): (103814).  [PMID:35198879]
7. Kieckhöfer E et al..  (2022)  Primary cilia suppress Ripk3-mediated necroptosis..  Cell Death Discov,  (477).  [PMID:36460631]
8. Chen IT et al..  (2021)  Promyelocytic leukemia protein targets MK2 to promote cytotoxicity..  EMBO Rep,  22  (12): (e52254).  [PMID:34633746]

Solution Calculators