Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu. (2023) Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway. BIOMATERIALS, 301 (122259). [PMID:37531777][10.1016/j.biomaterials.2023.122259]
2.Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107][10.2147/IJN.S134005]
3.Jinjin Chen, Lulu Zhou, Chunhui Wang, Yunhao Sun, Yonglin Lu, Ruihao Li, Xiaochun Hu, Mengyao Chen, Lv Chen, Keke Chai, Tianming Yao, Shuo Shi, Chunyan Dong. (2020) A multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan in esophageal cancer. Nanoscale, 12 (41):(21234-21247). [PMID:33063070][10.1039/D0NR06266A]
4.Hua Sun, Xiaotong Zhou, Baojian Wu. (2015) Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells. XENOBIOTICA, 45 (11):(945-953). [PMID:26068529][10.3109/00498254.2015.1033502]
References
1.Peter S et al.. (2016) Cell-based high-throughput compound screening reveals functional interaction between oncofetal HMGA2 and topoisomerase I.. Nucleic Acids Res, [PMID:27587582]
2.Winkler C et al.. (2021) SLFN11 informs on standard of care and novel treatments in a wide range of cancer models.. Br J Cancer, 124 (5):(951-962). [PMID:33339894]
3.Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu. (2023) Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway. BIOMATERIALS, 301 (122259). [PMID:37531777][10.1016/j.biomaterials.2023.122259]
4.Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107][10.2147/IJN.S134005]
5.Jinjin Chen, Lulu Zhou, Chunhui Wang, Yunhao Sun, Yonglin Lu, Ruihao Li, Xiaochun Hu, Mengyao Chen, Lv Chen, Keke Chai, Tianming Yao, Shuo Shi, Chunyan Dong. (2020) A multifunctional SN38-conjugated nanosystem for defeating myelosuppression and diarrhea induced by irinotecan in esophageal cancer. Nanoscale, 12 (41):(21234-21247). [PMID:33063070][10.1039/D0NR06266A]
6.Hua Sun, Xiaotong Zhou, Baojian Wu. (2015) Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells. XENOBIOTICA, 45 (11):(945-953). [PMID:26068529][10.3109/00498254.2015.1033502]
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I1926046