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7-Ethyl-10-hydroxycamptothecin - 98%, high purity , CAS No.86639-52-3

≥98%

CAS#: 86639-52-3
Formula: C₂₂H₂₀N₂O₅
Molecular Weight: 392.4
EC Number: 643-093-9
MDL number: MFCD06762720
PubChem CID: 104842
PubChem SID: 488187375

Item Number

E110128

Grouped product items
SKU	Size	Availability	Price
E110128-100mg	100mg	In stock	$94.90
E110128-500mg	500mg	In stock	$177.90
E110128-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$320.90
E110128-5g	5g	In stock	$1,441.90

DNA topoisomerase I inhibitor. Active metabolite of CPT-11.

View related series

quinolines

Basic Description

Synonyms	7-Ethyl-10-hydroxycamptothecin \| 86639-52-3 \| SN-38 \| SN 38 \| SN 38 lactone \| (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione \| SN38 \| 10-Hydroxy-7-ethylcamptothecin \| 7-Ethyl-10-hydroxy-20(S)-camptothecin \| NK012 \| NK 012 \| NK-
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

TOP1 Tclin DNA topoisomerase 1 (0 Activities)

Discover Target: TOP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (0 Activities)

Discover Target: ABCG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488187375
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488187375
IUPAC Name	(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
INCHI	InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChi Key	FJHBVJOVLFPMQE-QFIPXVFZSA-N
Canonical SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O
Isomeric SMILES	CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O
WGK Germany	3
RTECS	UQ0491000
Alternate CAS	86639-52-3
PubChem CID	104842
NSC Number	673596
MeSH Entry Terms	7 Ethyl 10 hydroxycamptothecin;7-ethyl-10-hydroxycamptothecin;Camptosar;Camptothecin 11;camptothecin-11;CPT 11;CPT-11;CPT11;irinotecan;irinotecan hydrochloride;Irrinotecan;NK012 compound;SN 38;SN 38 11;SN-38;SN-38-11;SN3811
Molecular Weight	392.4
Reaxy-Rn	4829984

Database links

PubChem SID	488187375

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot Number	Certificate Type	Date	Item
B2317760	Certificate of Analysis	Jan 07, 2023	E110128
B2317761	Certificate of Analysis	Jan 07, 2023	E110128
B2317767	Certificate of Analysis	Jan 07, 2023	E110128
B2317778	Certificate of Analysis	Jan 07, 2023	E110128
B2317803	Certificate of Analysis	Jan 07, 2023	E110128
B2317820	Certificate of Analysis	Jan 07, 2023	E110128
B2317862	Certificate of Analysis	Jan 07, 2023	E110128
I2207459	Certificate of Analysis	Jul 29, 2022	E110128
I2207460	Certificate of Analysis	Jul 29, 2022	E110128
I2207461	Certificate of Analysis	Jul 29, 2022	E110128
I2207462	Certificate of Analysis	Jul 29, 2022	E110128
K2327037	Certificate of Analysis	Jul 29, 2022	E110128

Chemical and Physical Properties

Sensitivity	heat sensitive
Specific Rotation[α]	+20.0 to +30.0 deg(C=0.2, THF)
Melt Point(°C)	217°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H341:Suspected of causing genetic defects
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
WGK Germany	3
RTECS	UQ0491000
Reaxy-Rn	4829984

FAQs and Articles

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Antibody-drug Conjugates: A Comprehensive Guide

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Metabolic signaling pathway

Categories: Technical articles

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Carbohydrate metabolism Lipid metabolism Glutamic acid metabolism Nucleotide metabolism

Citations of This Product

1. Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu. (2023) Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway. BIOMATERIALS, 301 (122259). [PMID:37531777]
2. Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107]

References

1. Peter S et al.. (2016) Cell-based high-throughput compound screening reveals functional interaction between oncofetal HMGA2 and topoisomerase I.. Nucleic Acids Res, [PMID:27587582]
2. Winkler C et al.. (2021) SLFN11 informs on standard of care and novel treatments in a wide range of cancer models.. Br J Cancer, 124 (5): (951-962). [PMID:33339894]
3. Lili Cheng, Peng Zhang, Yadong Liu, Zhuoyin Liu, Junjie Tang, Langtao Xu, Jie Liu. (2023) Multifunctional hybrid exosomes enhanced cancer chemo-immunotherapy by activating the STING pathway. BIOMATERIALS, 301 (122259). [PMID:37531777]
4. Linjie Yang, Jingyi Hong, Jing Di, Yifei Guo, Meihua Han, Meifeng Liu, Xiangtao Wang. (2023) 10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy. International Journal of Nanomedicine, [PMID:28553107]

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