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7-Ethyl-10-hydroxycamptothecin - 98%, high purity , CAS No.86639-52-3
DNA topoisomerase I inhibitor. Active metabolite of CPT-11.
Basic Description Synonyms 7-Ethyl-10-hydroxycamptothecin|86639-52-3|SN-38|SN 38|SN 38 lactone|(S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione|SN38|10-Hydroxy-7-ethylcamptothecin|7-Ethyl-10-hydroxy-20(S)-camptothecin|NK012|NK 012|NK- Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Dry ice
Names and Identifiers Pubchem Sid 488187375 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488187375 IUPAC Name (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione INCHI InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1 InChi Key FJHBVJOVLFPMQE-QFIPXVFZSA-N Canonical SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)O Isomeric SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O WGK Germany 3 RTECS UQ0491000 Alternate CAS 86639-52-3 PubChem CID 104842 NSC Number 673596 MeSH Entry Terms 7 Ethyl 10 hydroxycamptothecin;7-ethyl-10-hydroxycamptothecin;Camptosar;Camptothecin 11;camptothecin-11;CPT 11;CPT-11;CPT11;irinotecan;irinotecan hydrochloride;Irrinotecan;NK012 compound;SN 38;SN 38 11;SN-38;SN-38-11;SN3811 Molecular Weight 392.4 Reaxy-Rn 4829984
Chemical and Physical Properties Sensitivity heat sensitive Specific Rotation[α] +20.0 to +30.0 deg(C=0.2, THF) Melt Point(°C) 217°C
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS08 Signal Danger Hazard Statements H301: Toxic if swallowed
H341: Suspected of causing genetic defects
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P281: Use personal protective equipment as required.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
P318: if exposed or concerned, get medical advice.
WGK Germany 3 RTECS UQ0491000 Reaxy-Rn 4829984
References 1. Peter S et al.. (2016) Cell-based high-throughput compound screening reveals functional interaction between oncofetal HMGA2 and topoisomerase I.. Nucleic Acids Res, [PMID:27587582 ] 2. Winkler C et al.. (2021) SLFN11 informs on standard of care and novel treatments in a wide range of cancer models.. Br J Cancer, 124 (5): (951-962). [PMID:33339894 ]
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