Grouped product items

SKU

Size

Availability

Price

Qty

M111858-50mg

50mg

In stock

$137.90

M111858-100mg

100mg

Available within 4-8 weeks(?)

$248.90

M111858-250mg

250mg

In stock

$558.90

M111858-1g

In stock

$2,012.90

Basic Description

Synonyms	7-Methylxanthine \| 552-62-5 \| Heteroxanthine \| Heteroxanthin \| 7-Methylxanthin \| 2,6-Dihydroxy-7-methylpurine \| 7-Methyl-1H-purine-2,6(3H,7H)-dione \| Xanthine, 7-methyl- \| 7-methyl-3H-purine-2,6-dione \| 1H-Purine-2,6-dione, 3,7-dihydro-7-methyl- \| 3,7-Dihydro-7-methyl-1H-pur
Specifications & Purity	≥97%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Product Description	General description： 7-Methylxanthine is an oxopurine, which belongs to the class of xanthines. It may be synthesized by the reaction between 4-amino-1-methylimidazole-5-carboxamide and diethyl carbonate. description： 7-Methylxanthine can be used as a building block to synthesize tricyclic imidazo[2,1-i]purinone derivatives as potential adenosine receptor antagonists

Associated Targets(Human)

DNA2 Tbio DNA replication ATP-dependent helicase/nuclease DNA2 (0 Activities)

Discover Target: DNA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA2B Tclin Adenosine receptor A2b (0 Activities)

Discover Target: ADORA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 (0 Activities)

Discover Target: ADORA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GDA Tbio Guanine deaminase (0 Activities)

Discover Target: GDA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GDA Tbio Guanine deaminase (19 Activities)

Discover Target: GDA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DNA2 Tbio DNA replication ATP-dependent helicase/nuclease DNA2 (97 Activities)

Discover Target: DNA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adora2b Adenosine A2 receptor (1828 Activities)

Discover Target: Adora2b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-methyl-3H-purine-2,6-dione
INCHI	InChI=1S/C6H6N4O2/c1-10-2-7-4-3(10)5(11)9-6(12)8-4/h2H,1H3,(H2,8,9,11,12)
InChi Key	PFWLFWPASULGAN-UHFFFAOYSA-N
Canonical SMILES	CN1C=NC2=C1C(=O)NC(=O)N2
Isomeric SMILES	CN1C=NC2=C1C(=O)NC(=O)N2
WGK Germany	3
PubChem CID	68374
Molecular Weight	166.14
Beilstein	171027

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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5 results found

Lot Number	Certificate Type	Date	Item
D2425054	Certificate of Analysis	Jul 18, 2022	M111858
H2229420	Certificate of Analysis	Jul 18, 2022	M111858
H2229672	Certificate of Analysis	Jul 18, 2022	M111858
H2229717	Certificate of Analysis	Jul 18, 2022	M111858
H2229718	Certificate of Analysis	Jul 18, 2022	M111858

Chemical and Physical Properties

Solubility	Soluble in dimethyl sulfoxide. Insoluble in water.
Melt Point(°C)	≥300℃

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

Citations of This Product

1. Fan Yuzhuo, Li Jiarui, Huang Lvzhen, Wang Kai, Zhao Mingwei. (2022) 7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells. OPHTHALMIC RESEARCH, 65 (6): (678-684). [PMID:35724635]

References

1. S Gates,J O Miners. (1999-04-24) Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism.. British journal of clinical pharmacology, 47 ((3)): (299-305). [PMID:10215755]
2. Kouichi Mizuno,Akira Okuda,Misako Kato,Naho Yoneyama,Hiromi Tanaka,Hiroshi Ashihara,Tatsuhito Fujimura. (2003-01-16) Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.).. FEBS letters, 534 ((1-3)): (75-81). [PMID:12527364]
3. Swati Sucharita Dash,Sathyanarayana N Gummadi. (2007-06-08) Degradation kinetics of caffeine and related methylxanthines by induced cells of Pseudomonas sp.. Current microbiology, 55 ((1)): (56-60). [PMID:17554468]
4. Karsten Nödler,Maria Tsakiri,Tobias Licha. (2014-10-14) The impact of different proportions of a treated effluent on the biotransformation of selected micro-contaminants in river water microcosms.. International journal of environmental research and public health, 11 ((10)): (10390-10405). [PMID:25310538]
5. Kai He,Shinya Echigo,Yasuhiro Asada,Sadahiko Itoh. (2018-03-13) Determination of Caffeine and Its Metabolites in Wastewater Treatment Plants Using Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry.. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 34 ((3)): (349-354). [PMID:29526904]
6. Di Sun,Xueying Yang,Chao Zeng,Bo Li,Yi Wang,Chunzhi Zhang,Wenzhong Hu,Xianzhen Li,Ziqing Gao. (2020-02-06) Novel caffeine degradation gene cluster is mega-plasmid encoded in Paraburkholderia caffeinilytica CF1.. Applied microbiology and biotechnology, 104 ((7)): (3025-3036). [PMID:32009202]
7. Binxing Zhou,Cunqiang Ma,Chengqin Zheng,Tao Xia,Bingsong Ma,Xiaohui Liu. (2020-08-29) 3-Methylxanthine production through biodegradation of theobromine by Aspergillus sydowii PT-2.. BMC microbiology, 20 ((1)): (269-269). [PMID:32854634]
8. W A Tramontano,D A Phillips,C A Carman,A M Massaro. (1990-01-01) Nuclear incorporation of [adenine 14C]NAD is altered by compounds which affect poly(ADP-ribose) formation.. Phytochemistry, 29 ((1)): (31-33). [PMID:1367419]
9. H M Himmel,V Sadony,U Ravens. (1991-07-17) Quantitation of hypoxanthine in plasma from patients with ischemic heart disease: adaption of a high-performance liquid chromatographic method.. Journal of chromatography, 568 ((1)): (105-115). [PMID:1770088]
10. K Trier,E B Olsen,T Kobayashi,S M Ribel-Madsen. (1999-11-27) Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.. The British journal of ophthalmology, 83 ((12)): (1370-1375). [PMID:10574816]
11. Chun-xi Zhou,Jie Liao,Li Li. (2003-01-25) [Research on the separation of caffeine and its nine analogues by micellar electrokinetic capillary chromatography].. Se pu = Chinese journal of chromatography, 20 ((3)): (233-236). [PMID:12541944]
12. Dongmei Cui,Klaus Trier,Junwen Zeng,Kaili Wu,Minbin Yu,Jianmin Hu,Xiang Chen,Jian Ge. (2009-10-29) Effects of 7-methylxanthine on the sclera in form deprivation myopia in guinea pigs.. Acta ophthalmologica, 89 ((4)): (328-334). [PMID:19860777]
13. Fan Yuzhuo, Li Jiarui, Huang Lvzhen, Wang Kai, Zhao Mingwei. (2022) 7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells. OPHTHALMIC RESEARCH, 65 (6): (678-684). [PMID:35724635]

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7-Methylxanthine - 97%, high purity , CAS No.552-62-5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator