Grouped product items

SKU

Size

Availability

Price

Qty

N124837-250mg

250mg

Available within 1-2 weeks(?)

$29.90

N124837-1g

In stock

$91.90

N124837-5g

Available within 4-8 weeks(?)

$342.90

Basic Description

Synonyms	CRT0044876, >=98% (HPLC) \| CS-W015338 \| 7-Nitro-1H-indole-2-carboxylic acid \| BDBM50030281 \| 7-Nitroindole-2-carboxylic acid \| CCG-246292 \| EINECS 230-154-6 \| AKOS005135879 \| NSC 69877,7-NO2-ICA \| SW219854-1 \| AMY24828 \| 3',6'-Dihydroxy-3-oxo-3H-spiro[iso
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Selective APE1 inhibitor (IC 50 = 3 μM). Binds to the active site of APE1 and inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase. Potentiates the cytotoxicity of several DNA base-targeting compounds.
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (0 Activities)

Discover Target: FEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota (0 Activities)

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

crn-4 Cell death-related nuclease 4 (18 Activities)

Discover Target: crn-4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rnt Ribonuclease T (18 Activities)

Discover Target: rnt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488185960
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488185960
IUPAC Name	7-nitro-1H-indole-2-carboxylic acid
INCHI	InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)
InChi Key	BIUCOFQROHIAEO-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C(=C1)[N+](=O)[O-])NC(=C2)C(=O)O
Isomeric SMILES	C1=CC2=C(C(=C1)[N+](=O)[O-])NC(=C2)C(=O)O
WGK Germany	3
PubChem CID	81409
Molecular Weight	206.16

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
D2323850	Certificate of Analysis	Mar 08, 2023	N124837
F1516071	Certificate of Analysis	Mar 08, 2023	N124837
K2229229	Certificate of Analysis	Dec 07, 2022	N124837

Chemical and Physical Properties

Melt Point(°C)	264-266°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Junqiu Zhai, Fanglin Huang, Yunyun Yang, Xiaoxin Liu, Tiangang Luan, Jiewei Deng. (2023) Development of a Repair Enzyme Fluorescent Probe to Reveal the Intracellular DNA Damage Induced by Benzo[a]pyrene in Living Cells. ANALYTICAL CHEMISTRY, 95 (19): (7788–7795). [PMID:37130082] [10.1021/acs.analchem.3c01251]
2. Yingli Han, Yuehua Wang, Fangyu Zhou, Yuyang Jiang, Feng Liu. (2022) Molecular beacon-based DNA tetrahedrons for APE 1 activity detection in living cells. SENSORS AND ACTUATORS B-CHEMICAL, 355 (131258). [PMID:] [10.1016/j.snb.2021.131258]
3. Yuqiang Hu, Zhen Zhang, Weicong Ye, Wei Zhang, Minghao Hu, Wenqian Yuan, Hongbo Wang, Xianjin Xiao, Tongbo Wu. (2021) A DNA structure-mediated fluorescent biosensor for apurinic/apyrimidinic endonuclease 1 activity detection with ultra-high sensitivity and selectivity. SENSORS AND ACTUATORS B-CHEMICAL, 330 (129332). [PMID:] [10.1016/j.snb.2020.129332]
4. Yao Jiang, Xiangjuan Kong, Yanxialei Jiang, Wenjing Zhao, Huimin Zhou, Shusheng Zhang. (2020) DNA Nanodevices for Base Excision Repair Regulates ATP In Situ Imaging and Tumor Therapy. ACS Applied Bio Materials, 3 (12): (8507–8514). [PMID:35019620] [10.1021/acsabm.0c00884]

References

1. Junqiu Zhai, Fanglin Huang, Yunyun Yang, Xiaoxin Liu, Tiangang Luan, Jiewei Deng. (2023) Development of a Repair Enzyme Fluorescent Probe to Reveal the Intracellular DNA Damage Induced by Benzo[a]pyrene in Living Cells. ANALYTICAL CHEMISTRY, 95 (19): (7788–7795). [PMID:37130082] [10.1021/acs.analchem.3c01251]
2. Yingli Han, Yuehua Wang, Fangyu Zhou, Yuyang Jiang, Feng Liu. (2022) Molecular beacon-based DNA tetrahedrons for APE 1 activity detection in living cells. SENSORS AND ACTUATORS B-CHEMICAL, 355 (131258). [PMID:] [10.1016/j.snb.2021.131258]
3. Yuqiang Hu, Zhen Zhang, Weicong Ye, Wei Zhang, Minghao Hu, Wenqian Yuan, Hongbo Wang, Xianjin Xiao, Tongbo Wu. (2021) A DNA structure-mediated fluorescent biosensor for apurinic/apyrimidinic endonuclease 1 activity detection with ultra-high sensitivity and selectivity. SENSORS AND ACTUATORS B-CHEMICAL, 330 (129332). [PMID:] [10.1016/j.snb.2020.129332]
4. Yao Jiang, Xiangjuan Kong, Yanxialei Jiang, Wenjing Zhao, Huimin Zhou, Shusheng Zhang. (2020) DNA Nanodevices for Base Excision Repair Regulates ATP In Situ Imaging and Tumor Therapy. ACS Applied Bio Materials, 3 (12): (8507–8514). [PMID:35019620] [10.1021/acsabm.0c00884]

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7-Nitroindole-2-carboxylic acid - ≥97%(HPLC), high purity , CAS No.6960-45-8