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7-Nitroindole-2-carboxylic acid - 10mM in DMSO, high purity , CAS No.6960-45-8

2 Citations

10mM in DMSO

CAS#: 6960-45-8
Formula: C₉H₆N₂O₄
Molecular Weight: 206.16
EC Number: 230-154-6
PubChem CID: 81409

Item Number

N425572

Grouped product items
SKU	Size	Availability	Price	Qty
N425572-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Selective APE1 inhibitor

Basic Description

Synonyms	7-Nitroindole-2-carboxylic acid \| 6960-45-8 \| 7-Nitro-1H-indole-2-carboxylic acid \| CRT0044876 \| 1H-Indole-2-carboxylic acid, 7-nitro- \| NSC 69877 \| Indole-2-carboxylic acid, 7-nitro- \| CHEMBL1870764 \| MFCD00044720 \| 7-Nitro-1H-indole-2-carboxylic acid. \| 7-Nitroindole-2-car
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Selective APE1 inhibitor (IC 50 = 3 μM). Binds to the active site of APE1 and inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase. Potentiates the cytotoxicity of several DNA base-targeting compounds.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (0 Activities)

Discover Target: FEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa (0 Activities)

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota (0 Activities)

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 (12055 Activities)

Discover Target: FEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

crn-4 Cell death-related nuclease 4 (18 Activities)

Discover Target: crn-4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rnt Ribonuclease T (18 Activities)

Discover Target: rnt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-nitro-1H-indole-2-carboxylic acid
INCHI	InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)
InChi Key	BIUCOFQROHIAEO-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C(=C1)[N+](=O)[O-])NC(=C2)C(=O)O
Isomeric SMILES	C1=CC2=C(C(=C1)[N+](=O)[O-])NC(=C2)C(=O)O
WGK Germany	3
PubChem CID	81409
Molecular Weight	206.16

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

Citations of This Product

1. Junqiu Zhai, Fanglin Huang, Yunyun Yang, Xiaoxin Liu, Tiangang Luan, Jiewei Deng. (2023) Development of a Repair Enzyme Fluorescent Probe to Reveal the Intracellular DNA Damage Induced by Benzo[a]pyrene in Living Cells. ANALYTICAL CHEMISTRY, 95 (19): (7788–7795). [PMID:37130082]
2. Yingli Han, Yuehua Wang, Fangyu Zhou, Yuyang Jiang, Feng Liu. (2022) Molecular beacon-based DNA tetrahedrons for APE 1 activity detection in living cells. SENSORS AND ACTUATORS B-CHEMICAL, 355 (131258). [PMID:]

References

1. Junqiu Zhai, Fanglin Huang, Yunyun Yang, Xiaoxin Liu, Tiangang Luan, Jiewei Deng. (2023) Development of a Repair Enzyme Fluorescent Probe to Reveal the Intracellular DNA Damage Induced by Benzo[a]pyrene in Living Cells. ANALYTICAL CHEMISTRY, 95 (19): (7788–7795). [PMID:37130082]
2. Yingli Han, Yuehua Wang, Fangyu Zhou, Yuyang Jiang, Feng Liu. (2022) Molecular beacon-based DNA tetrahedrons for APE 1 activity detection in living cells. SENSORS AND ACTUATORS B-CHEMICAL, 355 (131258). [PMID:]

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7-Nitroindole-2-carboxylic acid - 10mM in DMSO, high purity , CAS No.6960-45-8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties