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7α,25-dihydroxycholesterol - >98%, high purity , CAS No.64907-22-8, Agonist of GPR183

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7α,25-dihydroxycholesterol - >98%, high purity , CAS No.64907-22-8, Agonist of GPR183

Moligand™

≥98%

CAS#: 64907-22-8
Formula: C₂₇H₄₆O₃
Molecular Weight: 418.652
PubChem CID: 11954197

Item Number

D130221

Grouped product items
SKU	Size	Availability	Price	Qty
D130221-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$221.90

Highly potent GPR183 (EBI2) agonist

View related series

EBI2/GPR183 GPCR/G Protein GPR183 Agonist

Basic Description

Synonyms	9beta,14beta,17alpha-cholest-5-ene-3beta,7alpha,25-triol \| 3beta,7alpha,25-Trihydroxycholest-5-ene \| cholest-5-en-3beta,7alpha,25-triol \| DTXSID001311434 \| Cholest-5-ene-3-b,7-a,25-triol \| AKOS032949724 \| CHEBI:37623 \| 7alpha,25-Dihydroxycholesterol, >=98
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Highly potent GPR183 (EBI2) agonist (EC50= 140 pM) and putative natural ligand for GPR183. Regulates migration of B and T cells expressing GPR183in vivo. Desensitizes B cells and reduces their movement to splenic follicles.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GPR183

Associated Targets(Human)

GPR183 Tchem G-protein coupled receptor 183 (2 Activities)

Discover Target: GPR183

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(3S,7S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
INCHI	InChI=1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1
InChi Key	BQMSKLCEWBSPPY-IKVTXIKFSA-N
Canonical SMILES	CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
Isomeric SMILES	C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C
WGK Germany	3
PubChem CID	11954197
Molecular Weight	418.652

Database links

CAS Registry No.	64907-22-8
PubChem CID	11954197
ChEBI	CHEBI:37623
RCSB PDB Ligand	KJX
GPCRdb Ligand	7α,25-dihydroxycholesterol

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 4.19, Max Conc. mM: 10 with gentle warming

Safety and Hazards(GHS)

WGK Germany	3

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