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7β-Hydroxycholesterol - >99%, high purity , CAS No.566-27-8, Agonist of GPR183

Moligand™
≥99%

CAS#: 566-27-8
Formula: C₂₇H₄₆O₂
Molecular Weight: 402.653
PubChem CID: 473141

Item Number

C130187

Grouped product items
SKU	Size	Availability	Price
C130187-1mg	1mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$149.90
C130187-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$499.90
C130187-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$799.90

View related series

GPR183 Agonist

Basic Description

Synonyms	7beta-Hydroxycholesterol\|566-27-8\|(3beta,7beta)-Cholest-5-ene-3,7-diol\|5-cholestene-3beta,7beta-diol\|7beta-Hydroxy Cholesterol\|7-HYDROXYCHOLESTEROL\|CHEBI:42989\|cholest-5-ene-3beta,7beta-diol\|7-Hydroxycholesterol, (7beta)-\|7.beta.-Hydroxycholesterol\|7\|A-hy
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of GPR183
Product Description	7β-Hydroxy Cholesterol is a metabolite of Cholesterol. Its membrane organizing properties may have implications in Altzheimer’s disease. It was used to study oxysterol-induced apoptosis in human endothelial cells

Associated Targets

RORC Tchem Nuclear receptor ROR-gamma 1 Activities

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORA Tchem Nuclear receptor ROR-alpha 1 Activities

Discover Target: RORA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GPR183 Tchem G-protein coupled receptor 183 1 Activities

Discover Target: GPR183

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NPC1L1 Tclin NPC1-like intracellular cholesterol transporter 1 0 Activities

Discover Target: NPC1L1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S,7R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
INCHI	InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24+,25+,26+,27-/m1/s1
InChi Key	OYXZMSRRJOYLLO-KGZHIOMZSA-N
Canonical SMILES	CC(C)CCCC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
Isomeric SMILES	C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C
WGK Germany	3
PubChem CID	473141
Molecular Weight	402.653

CAS Registry No.

PubChem CID

ChEBI

ChEMBL Ligand

RCSB PDB Ligand

GPCRdb Ligand

7β-hydroxycholesterol

Certificates

Certificate of Analysis(COA)

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8 results found

Lot Number	Certificate Type	Date	Item
D2226083	Certificate of Analysis	Feb 06, 2024	C130187
D2226086	Certificate of Analysis	Feb 06, 2024	C130187
L2320333	Certificate of Analysis	Dec 07, 2023	C130187
L2320334	Certificate of Analysis	Dec 07, 2023	C130187
L2320335	Certificate of Analysis	Dec 07, 2023	C130187
L2320336	Certificate of Analysis	Dec 07, 2023	C130187
L2320344	Certificate of Analysis	Dec 07, 2023	C130187
L2320346	Certificate of Analysis	Dec 07, 2023	C130187

Solubility

Soluble in Chloroform and Methanol

Sensitivity

Moisture sensitive

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