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7β-Hydroxycholesterol - >99%, high purity , CAS No.566-27-8, Agonist of GPR183
Basic Description Synonyms .DELTA.5-CHOLESTENE-3.BETA.,7.BETA.-DIOL | 7-HYDROXYCHOLESTEROL, (7.BETA.)- | UNII-N9616291J4 | LMST01010047 | CHOLEST-5-ENE-3,7-DIOL, (3.BETA.,7.BETA.)- | DB04706 | CS-0061837 | 7?-Hydroxy Cholesterol | 7-beta-OHC | CHEBI:42989 | Cholest-5-ene-3,7-diol, Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms 7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of GPR183 Product Description 7β-Hydroxy Cholesterol is a metabolite of Cholesterol. Its membrane organizing properties may have implications in Altzheimer’s disease.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (3S,7R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol INCHI InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24+,25+,26+,27-/m1/s1 InChi Key OYXZMSRRJOYLLO-KGZHIOMZSA-N Canonical SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C Isomeric SMILES C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C=C4[C@@]3(CC[C@@H](C4)O)C)O)C WGK Germany 3 PubChem CID 473141 Molecular Weight 402.653
Chemical and Physical Properties Solubility Soluble in Chloroform and Methanol Sensitivity Moisture sensitive
Citations of This Product 1. Ge Bai, Chuan-Guo Ma, Yu-Yuan Hu, Shu-Jing Guo, Tong Wang. (2023) Chemical conversions of free phytosterols during the bleaching of corn oil. FOOD CHEMISTRY, 412 (135512). [PMID:36731234 ] [10.1016/j.foodchem.2023.135512 ]
References 1. Ge Bai, Chuan-Guo Ma, Yu-Yuan Hu, Shu-Jing Guo, Tong Wang. (2023) Chemical conversions of free phytosterols during the bleaching of corn oil. FOOD CHEMISTRY, 412 (135512). [PMID:36731234 ] [10.1016/j.foodchem.2023.135512 ]
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