Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | AC-907/25014399 | 8-Quinolylamine | SY012863 | AC-10209 | BB 0221197 | CS-W007317 | Q4644259 | A0419 | BDBM32144 | BIDD:GT0148 | STK344576 | AM20050982 | 8-AMINOQUINOLINE | 8-amino-quinoline | BRN 0114474 | NCGC00184185-02 | quinolin-8-amine | AMINOQUINOL |
|---|---|
| Specifications & Purity | ≥98% |
| Storage Temp | Argon charged |
| Shipped In | Normal |
| Product Description | 8-Aminoquinoline fluoresce moderately to weakly in low dielectric media but not in strongly hydrogen-bonding or acidic aqueous media. The reaction of 8-aminoquinoline with chromium (III), manganese (II), iron (II) and (III), cobalt (II), nickel (II), copper (II), zinc (II), cadmium (II) and platinum (II) salts has been studied. |
Associated Targets(Human)
QPCT Tchem Glutaminyl-peptide cyclotransferase (0 Activities)
PSMD14 Tchem 26S proteasome non-ATPase regulatory subunit 14 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
POLI Tchem DNA polymerase iota (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
MMP1 Tchem Interstitial collagenase (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
MMP9 Tchem Matrix metalloproteinase-9 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
MMP2 Tchem 72 kDa type IV collagenase (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
MMP3 Tchem Stromelysin-1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
MMP8 Tchem Neutrophil collagenase (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
NCF1 Tbio Neutrophil cytosol factor 1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
TYR Tclin Tyrosinase (717 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HEK293 (82097 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
HepG2 (196354 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Jurkat (10389 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
QPCT Tchem Glutaminyl-peptide cyclotransferase (1121 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
POLI Tchem DNA polymerase iota (116820 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
NCF1 Tbio Neutrophil cytosol factor 1 (245 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PSMD14 Tchem 26S proteasome non-ATPase regulatory subunit 14 (475 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Histidine-rich protein (528 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mmp2 Matrix metalloproteinase-2 (12 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mmp9 Matrix metalloproteinase 9 (38 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Plasmodium falciparum (966862 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Ferriprotoporphyrin IX (165 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
lef Anthrax lethal factor (7585 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
fba Fructose-bisphosphate aldolase (8 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 488181314 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488181314 |
| IUPAC Name | quinolin-8-amine |
| INCHI | InChI=1S/C9H8N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,10H2 |
| InChi Key | WREVVZMUNPAPOV-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC2=C(C(=C1)N)N=CC=C2 |
| Isomeric SMILES | C1=CC2=C(C(=C1)N)N=CC=C2 |
| WGK Germany | 3 |
| RTECS | VA9627000 |
| PubChem CID | 11359 |
| Molecular Weight | 144.17 |
| Beilstein | 114474 |
| Reaxy-Rn | 114474 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I1521007 | Certificate of Analysis | May 08, 2023 | A105027 |
| F2315576 | Certificate of Analysis | Mar 08, 2023 | A105027 |
| F2315578 | Certificate of Analysis | Mar 08, 2023 | A105027 |
| F2315597 | Certificate of Analysis | Mar 08, 2023 | A105027 |
| F2315603 | Certificate of Analysis | Mar 08, 2023 | A105027 |
| F2315606 | Certificate of Analysis | Mar 08, 2023 | A105027 |
| F2315614 | Certificate of Analysis | Mar 08, 2023 | A105027 |
| B2322164 | Certificate of Analysis | Nov 21, 2022 | A105027 |
| B2322287 | Certificate of Analysis | Nov 21, 2022 | A105027 |
| L2206223 | Certificate of Analysis | Nov 21, 2022 | A105027 |
| L2206224 | Certificate of Analysis | Nov 21, 2022 | A105027 |
| L2206240 | Certificate of Analysis | Nov 21, 2022 | A105027 |
| H1809094 | Certificate of Analysis | Jun 15, 2022 | A105027 |
| H1809093 | Certificate of Analysis | Jun 15, 2022 | A105027 |
Show more⌵
Chemical and Physical Properties
| Solubility | Soluble in water. |
|---|---|
| Sensitivity | Air Sensitive |
| Boil Point(°C) | 174 °C/26 mmHg |
| Melt Point(°C) | 62-65°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | VA9627000 |
| Reaxy-Rn | 114474 |
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Citations of This Product
| 1. Yixuan Yao, Fudong Zeng, Liangqiang Wu, Shuo Xing, Qingbiao Yang, Yaoxian Li. (2023) A novel “on–off–on” near-infrared fluorescent probe for Cu2+ and S2− continuous detection based on dicyanoisoflurone derivatives, and its application in bacterial imaging. Analytical Methods, 15 (40): (5329-5340). [PMID:37791492] [10.1039/D3AY01339A] |
| 2. Fan Wu, Hao Li, Yang Pan, Yingjia Wang, Yonghui Sun, Jianming Pan. (2023) Sustainable utilization of palladium from industrial catalytic waste by a smart magnetic nano stirring robot. SEPARATION AND PURIFICATION TECHNOLOGY, 315 (123536). [PMID:] [10.1016/j.seppur.2023.123536] |
| 3. Zang Yu, Gao Shan, Jing Boyu, Sun Hong, Wang Jianjun, Liu Jiao, Miao Fengjuan, Xu Liang. (2023) Synthesis of Pd/conjugated microporous polymer heterogeneous catalysts via imine groups and high catalytic efficiency on Suzuki–Miyaura coupling reaction. JOURNAL OF MATERIALS SCIENCE, 58 (1): (170-185). [PMID:] [10.1007/s10853-022-08032-8] |
| 4. Fan Wu, Hao Li, Yang Pan, Yonghui Sun, Jianming Pan. (2023) Bioinspired construction of magnetic nano stirring rods with radially aligned dual mesopores and intrinsic rapid adsorption of palladium. JOURNAL OF HAZARDOUS MATERIALS, 441 (129917). [PMID:36099737] [10.1016/j.jhazmat.2022.129917] |
| 5. Selvaraj Muthusamy, Siqi Yin, Kanagaraj Rajalakshmi, Suci Meng, Dongwei Zhu, Meng Xie, Jimin Xie, Rathna Silviya Lodi, Yuanguo Xu. (2022) Development of a quinoline-derived turn-on fluorescent probe for real time detection of hydrazine and its applications in environment and bioimaging. DYES AND PIGMENTS, 206 (110618). [PMID:] [10.1016/j.dyepig.2022.110618] |
| 6. Kanagaraj Rajalakshmi, Selvaraj Muthusamy, Yun-Sik Nam, Yujun Li, Kang-Bong Lee, Yuanguo Xu. (2022) A new recognition moiety diphenylborinate in the detection of pyruvate via Lewis acid/base sensing pathway and its bioimaging applications. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 267 (120457). [PMID:34653848] [10.1016/j.saa.2021.120457] |
| 7. Selvaraj Muthusamy, Long Zhao, Kanagaraj Rajalakshmi, Dongwei Zhu, Shengjun Wang, John Mack, Kang-Bong Lee, Long Zhang, Weihua Zhu. (2022) Quantitative Hg2+ detection via forming three coordination complexes using a lysosome targeting quinoline - Fisher aldehyde fluorophore. TALANTA, 236 (122884). [PMID:34635264] [10.1016/j.talanta.2021.122884] |
| 8. Brian Musikavanhu, Selvaraj Muthusamy, Dongwei Zhu, Zhaoli Xue, Qian Yu, Choonzo N. Chiyumba, John Mack, Tebello Nyokong, Shengjun Wang, Long Zhao. (2022) A simple quinoline-thiophene Schiff base turn-off chemosensor for Hg2+ detection: spectroscopy, sensing properties and applications. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 264 (120338). [PMID:34482149] [10.1016/j.saa.2021.120338] |
| 9. Selvaraj Muthusamy, Long Zhao, Kanagaraj Rajalakshmi, Dongwei Zhu, Rodah Soy, John Mack, Tebello Nyokong, Shengjun Wang, Kang-Bong Lee, Weihua Zhu. (2021) Turn-on detection of cysteine by a donor-acceptor type quinoline fluorophore: Exploring the sensing strategy and performance in bioimaging. DYES AND PIGMENTS, 193 (109556). [PMID:] [10.1016/j.dyepig.2021.109556] |
| 10. Xinyu Wang, Zhuo Li, Jiaojiao Nie, Liangqiang Wu, Weihong Chen, Shaolong Qi, Hai Xu, Jianshi Du, Yaming Shan, Qingbiao Yang. (2021) A novel hydrophilic fluorescent probe for Cu2+ detection and imaging in HeLa cells. RSC Advances, 11 (17): (10264-10271). [PMID:35423512] [10.1039/D0RA09894A] |
| 11. Selvaraj Muthusamy, Kanagaraj Rajalakshmi, Qingxiang Xu, Yan Chen, Long Zhao, Weihua Zhu. (2020) An azido coumarin-quinoline conjugated fluorogenic dye: Utilizing amide-iminol tautomerism for H2S detection in live MCF-7 cells. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 238 (118345). [PMID:32387916] [10.1016/j.saa.2020.118345] |
| 12. Jian Lu, Yingying Qin, Chao Yu, Xinyu Lin, Minjia Meng, Yongsheng Yan, Hougang Fan, Yilin Wu, Chunxiang Li. (2020) Stable, regenerable and 3D macroporous Pd (II)-imprinted membranes for efficient treatment of electroplating wastewater. SEPARATION AND PURIFICATION TECHNOLOGY, 235 (116220). [PMID:] [10.1016/j.seppur.2019.116220] |
| 13. Bing Zhang, Shixing Wang, Likang Fu, Libo Zhang. (2018) Synthesis and Evaluation of 8-Aminoquinoline-Grafted Poly(glycidyl methacrylate) for the Recovery of Pd(II) from Highly Acidic Aqueous Solutions. Polymers, 10 (4): (437). [PMID:30966472] [10.3390/polym10040437] |
| 14. Chen Yalin, Mei Tao, Chen Yi, Wang Jianying, Li Jinhua, Wang Xianbao. (2017) 8-aminoquinoline functionalized graphene oxide for simultaneous determination of guanine and adenine. JOURNAL OF SOLID STATE ELECTROCHEMISTRY, 21 (5): (1357-1364). [PMID:] [10.1007/s10008-016-3492-0] |
| 15. Wei Zhang, Min Zhu, Feng Wang, Danhui Cao, Jennifer Jin Ruan, Weike Su, Benfang Helen Ruan. (2016) Mono-sulfonated tetrazolium salt based NAD(P)H detection reagents suitable for dehydrogenase and real-time cell viability assays. ANALYTICAL BIOCHEMISTRY, 509 (33). [PMID:27387057] [10.1016/j.ab.2016.06.026] |
| 16. Yi Pan, Yupeng Shi, Zhihua Chen, Junying Chen, Mengfei Hou, Zhanpeng Chen, Cheuk-Wing Li, Changqing Yi. (2016) Design of Multiple Logic Gates Based on Chemically Triggered Fluorescence Switching of Functionalized Polyethylenimine. ACS Applied Materials & Interfaces, 8 (14): (9472–9482). [PMID:27007856] [10.1021/acsami.6b02080] |
| 17. Zhaomin Zhang, Yupeng Shi, Yi Pan, Xin Cheng, Lulu Zhang, Junying Chen, Mei-Jin Li, Changqing Yi. (2014) Quinoline derivative-functionalized carbon dots as a fluorescent nanosensor for sensing and intracellular imaging of Zn2+. Journal of Materials Chemistry B, 2 (31): (5020-5027). [PMID:32261835] [10.1039/C4TB00677A] |
| 18. Xin Tian, Zhengping Dong, Rou Wang, Jiantai Ma. (2013) A quinoline group modified Fe3O4@SiO2 nanoparticles for sequential detection of Zn2+ and hydrogen sulfide in aqueous solution and its logic behavior. SENSORS AND ACTUATORS B-CHEMICAL, 183 (446). [PMID:] [10.1016/j.snb.2013.03.124] |
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