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8-Bromo-cAMP sodium salt - 99%, high purity , CAS No.76939-46-3

≥99%

CAS#: 76939-46-3
Formula: C₁₀H₁₀BrN₅NaO₆P
Molecular Weight: 430.08
MDL number: MFCD00005844
PubChem CID: 23702958

Item Number

B304590

Grouped product items
SKU	Size	Availability	Price
B304590-10mg	10mg	In stock	$67.90
B304590-25mg	25mg	In stock	$151.90
B304590-50mg	50mg	In stock	$253.90
B304590-100mg	100mg	In stock	$456.90
B304590-250mg	250mg	In stock	$1,027.90
B304590-1g	1g	In stock	$3,698.90

cAMP analog. PKA activator.

Basic Description

Synonyms	8-Br-Camp sodium salt \| 8-Br-cAMP sodium \| Q27121418 \| SMR000326869 \| C10H10BrN5NaO6P \| HB0090 \| 8-Br-cAMP sodium salt \| 8-BR-CAMP NA \| 8-Bromo-cAMP(sodium salt) \| 8-Bromo-cAMPsodiumsalt \| C90265 \| HMS3412M07 \| PD019065 \| CS-0011049 \| MLS000860010 \| Adeno
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Cell-permeable cAMP analog. Activates PKA. Inhibits cell growth, decreases proliferation and increases differentiation. Additionally induces apoptosis. Also improves reprogramming efficiency of fibroblast cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

PRKAR1A Tbio cAMP-dependent protein kinase type I-alpha regulatory subunit (18 Activities)

Discover Target: PRKAR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKAR2A Tchem cAMP-dependent protein kinase type II-alpha regulatory subunit (246 Activities)

Discover Target: PRKAR2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)

Discover Target: RAPGEF3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAPGEF4 Tchem Rap guanine nucleotide exchange factor 4 (11476 Activities)

Discover Target: RAPGEF4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hcn2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (15 Activities)

Discover Target: Hcn2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cnga2 Cyclic nucleotide-gated olfactory channel (5 Activities)

Discover Target: Cnga2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cnga2 CNGA2/CNGA4/CNGB1 (5 Activities)

Discover Target: Cnga2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	sodium;(4aR,6R,7R,7aS)-6-(6-amino-8-bromopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol
INCHI	InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChi Key	DMRMZQATXPQOTP-GWTDSMLYSA-M
Canonical SMILES	C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-].[Na+]
Isomeric SMILES	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-].[Na+]
PubChem CID	23702958
Molecular Weight	430.08

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
K2212148	Certificate of Analysis	Aug 08, 2022	B304590
K2212151	Certificate of Analysis	Aug 08, 2022	B304590
K2212152	Certificate of Analysis	Aug 08, 2022	B304590
K2212153	Certificate of Analysis	Aug 08, 2022	B304590
K2212156	Certificate of Analysis	Aug 08, 2022	B304590
K2212404	Certificate of Analysis	Aug 08, 2022	B304590

Solubility

H2O: 100 mg/mL

Sensitivity

Light sensitive,Moisture sensitive

References

1. Zhou M et al.. (2021) Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization.. J Adv Res, 30 (15-25). [PMID:34026283]
2. Tishchenko A et al.. (2020) Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells.. Cancers (Basel), 12 (10): [PMID:33003486]
3. Chen Y et al.. (2021) Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway.. Front Physiol, 12 (642274). [PMID:33868005]
4. Han M et al.. (2022) Increased expression of HMGB1 in the implantation phase endometrium is related to recurrent implantation failure.. Mol Biol Rep, 49 (3): (1701-1710). [PMID:35031923]
5. Zhou X et al.. (2020) Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity.. Front Cell Dev Biol, 8 (105). [PMID:32158757]
6. Zhou M et al.. (2016) miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis.. Hum Reprod, [PMID:27619769]

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