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SKU

Size

Availability

Price

Qty

H111087-25g

25g

In stock

$23.90

H111087-100g

100g

Available within 4-8 weeks(?)

$85.90

Basic Description

Synonyms	8-Hydroxyquinaldine \| 826-81-3 \| 2-Methylquinolin-8-ol \| 2-Methyl-8-quinolinol \| 2-Methyl-8-hydroxyquinoline \| 8-Quinolinol, 2-methyl- \| 8-HYDROXY-2-METHYLQUINOLINE \| 2-Methyloxine \| Hydroxyquinaldine \| 8-Hydroxyqinaldine \| 2-Methyl-quinolin-8-ol \| CHEMBL316892 \| NSC-58553 \| 7W631
Specifications & Purity	≥98%
Shipped In	Normal
Product Description	2-Methyl-8-quinolinol is a methyl substituted quinolinol derivative that shows fungicidal property.It can also undergo complexation with transition metal complexes. 2-Methyl-8-quinolinol (HqMe) may be used as a ligand for preparing bis (2-methyl-8-quinolinolato) aluminum(III)-μ-oxo-bis (2-methyl-8-quinolinolato ) aluminum (III). It may also be used in the preparation of a scandium 2-methyl-8-quinolinolate complex [Sc(qMe)4(H)].

Associated Targets(Human)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP1 Tchem Interstitial collagenase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

METAP2 Tchem Methionine aminopeptidase 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NOS2 Tchem Nitric oxide synthase, inducible (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP3 Tchem Stromelysin-1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP8 Tchem Neutrophil collagenase (0 Activities)

Discover Target: MMP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

METAP1 Tchem Methionine aminopeptidase 1 (0 Activities)

Discover Target: METAP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

Discover Target: ALOX5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

METAP1 Tchem Methionine aminopeptidase 1 (614 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

METAP2 Tchem Methionine aminopeptidase 2 (1512 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

K562 (73714 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLT-4 (49676 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-937 (7138 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

T47D (39041 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

Discover Target: SMAD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Nos2 Nitric oxide synthase, inducible (3573 Activities)

Discover Target: Nos2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

pol Human immunodeficiency virus type 1 integrase (9041 Activities)

Discover Target: pol

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania panamensis (230 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lef Anthrax lethal factor (7585 Activities)

Discover Target: lef

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

botA Botulinum neurotoxin type A (1303 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Serum (58 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Burkholderia thailandensis (182 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488181817
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181817
IUPAC Name	2-methylquinolin-8-ol
INCHI	InChI=1S/C10H9NO/c1-7-5-6-8-3-2-4-9(12)10(8)11-7/h2-6,12H,1H3
InChi Key	NBYLBWHHTUWMER-UHFFFAOYSA-N
Canonical SMILES	CC1=NC2=C(C=CC=C2O)C=C1
Isomeric SMILES	CC1=NC2=C(C=CC=C2O)C=C1
WGK Germany	2
RTECS	VC7920000
PubChem CID	13224
UN Number	3077
Molecular Weight	159.18
Beilstein	119194
Reaxy-Rn	119194

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
E2406086	Certificate of Analysis	Mar 22, 2024	H111087
E2406142	Certificate of Analysis	Mar 22, 2024	H111087
D2314554	Certificate of Analysis	May 31, 2022	H111087
F2220246	Certificate of Analysis	May 31, 2022	H111087
F2220257	Certificate of Analysis	May 31, 2022	H111087

Chemical and Physical Properties

Solubility	Insoluble in water;Solubility in Methanol almost transparency
Flash Point(°F)	282.2 °F
Flash Point(°C)	139℃
Boil Point(°C)	267°C
Melt Point(°C)	73°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09
Signal	Warning
Hazard Statements	H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P391:Collect spillage.
WGK Germany	2
RTECS	VC7920000
Reaxy-Rn	119194

References

1. Jennifer A Jacobsen,Jessica L Fullagar,Melissa T Miller,Seth M Cohen. (2010-12-30) Identifying chelators for metalloprotein inhibitors using a fragment-based approach.. Journal of medicinal chemistry, 54 ((2)): (591-602). [PMID:21189019]
2. Qi-Pin Qin,Zhen-Feng Chen,Jiao-Lan Qin,Xiao-Ju He,Yu-Lan Li,Yan-Cheng Liu,Ke-Bin Huang,Hong Liang. (2015-01-13) Studies on antitumor mechanism of two planar platinum(II) complexes with 8-hydroxyquinoline: synthesis, characterization, cytotoxicity, cell cycle and apoptosis.. European journal of medicinal chemistry, 92 (302-313). [PMID:25575314]
3. Zabiulla, V Vigneshwaran, A Begum Bushra, G S Pavankumar, B T Prabhakar, Shaukath Ara Khanum,. (2017-09-02) Design and synthesis of conjugated azo-hydrazone analogues using nano BF. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, ( 419-428 ). [PMID:28863382]
4. Kristiana T Santoso,Ayana Menorca,Chen-Yi Cheung,Gregory M Cook,Bridget L Stocker,Mattie S M Timmer. (2019-07-03) The synthesis and evaluation of quinolinequinones as anti-mycobacterial agents.. Bioorganic & medicinal chemistry, 27 ((16)): (3532-3545). [PMID:31262663]
5. Jakub Wantulok,Marcin Szala,Andrea Quinto,Jacek E Nycz,Stefania Giannarelli,Romana Sokolová,Maria Książek,Joachim Kusz. (2020-05-02) Synthesis, Electrochemical and Spectroscopic Characterization of Selected Quinolinecarbaldehydes and Their Schiff Base Derivatives.. Molecules (Basel, Switzerland), 25 ((9)): [PMID:32354039]
6. Kelly L Summers,M Jake Pushie,George J Sopasis,Ashley K James,Natalia V Dolgova,Dimosthenis Sokaras,Thomas Kroll,Hugh H Harris,Ingrid J Pickering,Graham N George. (2020-09-17) Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines.. Inorganic chemistry, 59 ((19)): (13858-13874). [PMID:32936627]

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8-Hydroxyquinaldine - 98%, high purity , CAS No.826-81-3