Grouped product items

SKU

Size

Availability

Price

Qty

H134497-10mg

10mg

Available within 8-12 weeks(?)

$17.90

H134497-25mg

25mg

Available within 8-12 weeks(?)

$35.90

H134497-50mg

50mg

Available within 8-12 weeks(?)

$56.90

H134497-100mg

100mg

Available within 8-12 weeks(?)

$90.90

H134497-250mg

250mg

Available within 8-12 weeks(?)

$154.90

H134497-500mg

500mg

Available within 8-12 weeks(?)

$261.90

H134497-1g

Available within 8-12 weeks(?)

$417.90

Basic Description

Synonyms	5852-78-8 \| IOX1 \| 8-Hydroxyquinoline-5-Carboxylic Acid \| 8-Hydroxy-5-quinolinecarboxylic acid \| 5-Carboxy-8-hydroxyquinoline \| IOX 1 \| IOX-1 \| JM015YQC1C \| CHEMBL1230640 \| IOX1 compound \| 8XQ \| 5-carboxy-8HQ \| 5-Quinolinecarboxylic acid, 8-hydroxy- \| UNII-JM015YQC1C \| 4bio \| 4jht \| 4ie
Specifications & Purity	Moligand™, ≥97%(HPLC)
Biochemical and Physiological Mechanisms	Histone demethylase JMJD inhibitor (IC50values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. The IC50 value of iox1 was
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of egl-9 family hypoxia inducible factor 1;Inhibitor of lysine demethylase 3A;Inhibitor of lysine demethylase 4C;Inhibitor of lysine demethylase 6B

Associated Targets(Human)

EGLN1 Tclin Egl nine homolog 1 (1 Activities)

Discover Target: EGLN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4C Tchem Lysine-specific demethylase 4C (3 Activities)

Discover Target: KDM4C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM6B Tchem Lysine-specific demethylase 6B (3 Activities)

Discover Target: KDM6B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM3A Tchem Lysine-specific demethylase 3A (3 Activities)

Discover Target: KDM3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E (4 Activities)

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCF7 (126967 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGLN1 Tclin Egl nine homolog 1 (1702 Activities)

Discover Target: EGLN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4D Tchem Lysine-specific demethylase 4D (224 Activities)

Discover Target: KDM4D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)

Discover Target: KDM4C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)

Discover Target: L3MBTL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM3A Tchem Lysine-specific demethylase 3A (116 Activities)

Discover Target: KDM3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM2A Tchem Lysine-specific demethylase 2A (198 Activities)

Discover Target: KDM2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6B Tchem Lysine-specific demethylase 6B (280 Activities)

Discover Target: KDM6B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6A Tchem Lysine-specific demethylase 6A (39 Activities)

Discover Target: KDM6A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5C Tchem Lysine-specific demethylase 5C (224 Activities)

Discover Target: KDM5C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTO Tchem Alpha-ketoglutarate-dependent dioxygenase FTO (473 Activities)

Discover Target: FTO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4B Tchem Lysine-specific demethylase 4B (165 Activities)

Discover Target: KDM4B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALKBH5 Tchem RNA demethylase ALKBH5 (134 Activities)

Discover Target: ALKBH5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TET2 Tchem Methylcytosine dioxygenase TET2 (57 Activities)

Discover Target: TET2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A085R Prolyl 4-hydroxylase (72 Activities)

Discover Target: A085R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

alkB Alpha-ketoglutarate-dependent dioxygenase AlkB (6 Activities)

Discover Target: alkB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	8-hydroxyquinoline-5-carboxylic acid
INCHI	InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChi Key	JGRPKOGHYBAVMW-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
Isomeric SMILES	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
WGK Germany	3
PubChem CID	459617
Molecular Weight	189.17

Database links

BindingDB Ligand	50396018
PubChem CID	459617
CAS Registry No.	5852-78-8
ChEMBL Ligand	CHEMBL1230640
RCSB PDB Ligand	8XQ

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot Number	Certificate Type	Date	Item
D2422096	Certificate of Analysis	Apr 11, 2024	H134497
D2422100	Certificate of Analysis	Apr 11, 2024	H134497
D2422102	Certificate of Analysis	Apr 11, 2024	H134497
D2422104	Certificate of Analysis	Apr 11, 2024	H134497
D2422106	Certificate of Analysis	Apr 11, 2024	H134497
D2422108	Certificate of Analysis	Apr 11, 2024	H134497
D2422110	Certificate of Analysis	Apr 11, 2024	H134497
D2422112	Certificate of Analysis	Apr 11, 2024	H134497
D2422113	Certificate of Analysis	Apr 11, 2024	H134497
D2422114	Certificate of Analysis	Apr 11, 2024	H134497
D2422115	Certificate of Analysis	Apr 11, 2024	H134497
D2422116	Certificate of Analysis	Apr 11, 2024	H134497
D2422117	Certificate of Analysis	Apr 11, 2024	H134497

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 18.92, Max Conc. mM: 100; Solvent:1eq. NaOH, Max Conc. mg/mL: 18.92, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

Alternative Products

References

1. Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC et al.. (2014) A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1.. ChemMedChem, 9 (3): (566-71). [PMID:24504543]
2. Unemura K et al.. (2022) A neuronal cell-based reporter system for monitoring the activity of HDAC2.. SLAS Discov, 27 (8): (440-447). [PMID:36240996]

Solution Calculators

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8-Hydroxyquinoline-5-carboxylic Acid - ≥97% (HPLC), high purity , CAS No.5852-78-8, Inhibitor of egl-9 family hypoxia inducible factor 1;Inhibitor of lysine demethylase 3A;Inhibitor of lysine demethylase 4C;Inhibitor of lysine demethylase 6B

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

more

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
H134497-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$17.90
H134497-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$35.90
H134497-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$56.90
H134497-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$90.90
H134497-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$154.90
H134497-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$261.90
H134497-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$417.90