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9-β-D-Arabinofuranosylguanine Hydrate - >98.0%(HPLC), high purity , CAS No.38819-10-2
DNA synthesis inhibitor; Apoptosis inducer; Antimetabolite and antineoplastic
Basic Description Synonyms 38819-10-2 | 9-beta-d-Arabinofuranosylguanine | 9-(beta-D-Arabinofuranosyl)guanine | Ara-G hydrate | 9-Arabinofuranosylguanine | 9-beta-Arabinosylguanine | Guanine arabinoside | Ara-G | 0Z99WX0GPF | CHEMBL240933 | CHEBI:73141 | CID 65412 | 9-(b-d-arabinofuranosyl)guanine | 2-amino Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Nucleoside analog. Converted by cellular kinases to the active 5'-triphosphate (Ara-GTP) and subsequently incorporated into DNA leading to inhibition of DNA synthesis and apoptosis. Storage Temp Store at 2-8°C Shipped In Wet ice Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-amino-9-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one INCHI InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1 InChi Key NYHBQMYGNKIUIF-FJFJXFQQSA-N Canonical SMILES C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(NC2=O)N Isomeric SMILES C1=NC2=C(N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N=C(NC2=O)N RTECS MF8301000 PubChem CID 135499520 Molecular Weight 283.24 Reaxy-Rn 1225954
Chemical and Physical Properties Sensitivity Heat Sensitive Melt Point(°C) 225°C(lit.)
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H341: Suspected of causing genetic defects
H351: Suspected of causing cancer
H372: Causes damage to organs through prolonged or repeated exposure
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P281: Use personal protective equipment as required.
P270: Do not eat, drink or smoke when using this product.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
P319: Get medical help if you feel unwell.
RTECS MF8301000 Reaxy-Rn 1225954
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