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9-Oxo-10(9H)-acridineacetic acid - >98.0%(HPLC), high purity , CAS No.38609-97-1
Murine-selective STING agonist
Basic Description
| Synonyms | 10-Carboxymethyl-10H-acridine-9-one sodium salt | CRIDANIMOD [WHO-DD] | 10-carboxymethyl-9-acridanone;10-CMA;XBIO-101;9-Oxo-10(9H)-acridineacetic acid | CBDivE_005011 | 10-(Carboxymethyl)-9(10H)acridone | 10-(Carboxymethyl)-9(10H)-acridone | 2-(9-oxo-10-a |
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| Specifications & Purity | ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | STING agonist; murine-selective (Kd= 3.5 μM). Triggers type I IFN response in murine macrophages, with no effect on human STING signaling. |
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| Storage Temp | Store at 2-8°C |
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| Shipped In | Wet ice |
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| Product Description | 9-Oxo-10(9H)-acridineacetic acid and its analogs,as interferon inducers,are used for studying their potential activity. |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 2-(9-oxoacridin-10-yl)acetic acid |
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| INCHI | InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18) |
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| InChi Key | UOMKBIIXHQIERR-UHFFFAOYSA-N |
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| Canonical SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O |
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| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O |
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| WGK Germany | 3 |
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| RTECS | AR7190000 |
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| PubChem CID | 38072 |
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| Molecular Weight | 253.25 |
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| Beilstein | 227508 |
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| Reaxy-Rn | 227508 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 25.32, Max Conc. mM: 100 |
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| Melt Point(°C) | 289°C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
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| WGK Germany | 3 |
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| RTECS | AR7190000 |
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| Reaxy-Rn | 227508 |
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