Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
P136335-250mg | 250mg | In stock | $35.90 | |
P136335-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $109.90 | |
P136335-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $361.90 |
Selective TRPM4 blocker
Synonyms | Phenanthren-9-ol|9-PHENANTHROL|484-17-3|9-Hydroxyphenanthrene|9-Phenanthrenol|NSC 50554|CHEBI:28820|9FYU45OV9H|CHEMBL2407182|DTXSID9047592|9-Hydroxyphenanthrene; NSC 50554|MFCD00082298|NSC-50554|CCRIS 1840|EINECS 207-602-4|UNII-9FYU45OV9H|BRN 2047057|phen |
---|---|
Specifications & Purity | Moligand™, technical grade |
Biochemical and Physiological Mechanisms | Selective TRPM4 blocker (IC 50 = 20 μM). Modulates smooth muscle contraction. Reduces LPS-induced cell death. Promotes angiogenesis. Shows cardioprotective and anti-ischemic effects in vivo. |
Shipped In | Normal |
Grade | Moligand™, technical grade |
Action Type | CHANNEL BLOCKER |
Mechanism of action | Channel blocker of TRPM4 |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | phenanthren-9-ol |
---|---|
INCHI | InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H |
InChi Key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O |
Isomeric SMILES | C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O |
WGK Germany | 3 |
RTECS | SF8288000 |
PubChem CID | 10229 |
Molecular Weight | 194.23 |
CAS Registry No. | 484-17-3 |
---|---|
PubChem CID | 10229 |
ChEMBL Ligand | CHEMBL2407182 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | SF8288000 |
1. Guinamard R, Hof T, Del Negro CA. (2014) The TRPM4 channel inhibitor 9-phenanthrol.. Br J Pharmacol, 171 (7): (1600-13). [PMID:24433510] |