Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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P136335-250mg | 250mg | In stock | $35.90 | |
P136335-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $109.90 | |
P136335-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $361.90 |
Selective TRPM4 blocker
Synonyms | HY-108457 | NSC50554 | NSC-50554 | UNII-9FYU45OV9H | DTXCID7027592 | DZKIUEHLEXLYKM-UHFFFAOYSA- | 4-06-00-04937 (Beilstein Handbook Reference) | Tox21_300618 | BRN 2047057 | GTPL4114 | SY113803 | Phenanthren-9-ol | SCHEMBL508755 | BDBM50526033 | CCRIS 184 |
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Specifications & Purity | Moligand™, technical grade |
Biochemical and Physiological Mechanisms | Selective TRPM4 blocker (IC 50 = 20 μM). Modulates smooth muscle contraction. Reduces LPS-induced cell death. Promotes angiogenesis. Shows cardioprotective and anti-ischemic effects in vivo. |
Shipped In | Normal |
Grade | Moligand™, technical grade |
Action Type | CHANNEL BLOCKER |
Mechanism of action | Channel blocker of TRPM4 |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | phenanthren-9-ol |
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INCHI | InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H |
InChi Key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O |
Isomeric SMILES | C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O |
WGK Germany | 3 |
RTECS | SF8288000 |
PubChem CID | 10229 |
Molecular Weight | 194.23 |
CAS Registry No. | 484-17-3 |
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PubChem CID | 10229 |
ChEMBL Ligand | CHEMBL2407182 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | SF8288000 |
1. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang. (2024) Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes. JOURNAL OF CHROMATOGRAPHY A, 1715 (464625). [PMID:38171066] |
2. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] |
3. Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang. (2023) High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122610). [PMID:] |
4. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2023) Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. JOURNAL OF HAZARDOUS MATERIALS, 441 (129920). [PMID:36099739] |
5. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2022) Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations. Environmental Science-Nano, 9 (9): (3562-3580). [PMID:] |
6. Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong. (2022) Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content. QUIMICA NOVA, 45 (2): (145-151). [PMID:] |
7. Cholho Choe, Ling Yang, Zhanao Lv, Wanling Mo, Zhuqi Chen, Guangxin Li, Guochuan Yin,. (2015-04-24) Redox-inactive metal ions promoted the catalytic reactivity of non-heme manganese complexes towards oxygen atom transfer.. Dalton transactions (Cambridge, England : 2003), 44 ((19)): ( 9182-9192 ). [PMID:25904197] |
1. Guinamard R, Hof T, Del Negro CA. (2014) The TRPM4 channel inhibitor 9-phenanthrol.. Br J Pharmacol, 171 (7): (1600-13). [PMID:24433510] |
2. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang. (2024) Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes. JOURNAL OF CHROMATOGRAPHY A, 1715 (464625). [PMID:38171066] |
3. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] |
4. Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang. (2023) High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122610). [PMID:] |
5. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2023) Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. JOURNAL OF HAZARDOUS MATERIALS, 441 (129920). [PMID:36099739] |
6. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2022) Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations. Environmental Science-Nano, 9 (9): (3562-3580). [PMID:] |
7. Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong. (2022) Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content. QUIMICA NOVA, 45 (2): (145-151). [PMID:] |
8. Cholho Choe, Ling Yang, Zhanao Lv, Wanling Mo, Zhuqi Chen, Guangxin Li, Guochuan Yin,. (2015-04-24) Redox-inactive metal ions promoted the catalytic reactivity of non-heme manganese complexes towards oxygen atom transfer.. Dalton transactions (Cambridge, England : 2003), 44 ((19)): ( 9182-9192 ). [PMID:25904197] |