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A 1120 - 98%, high purity , CAS No.1152782-19-8, Inhibitor of retinol binding protein 4
High affinity retinol-binding protein 4 (RBP4) ligand
Basic Description Synonyms GTPL8792 | HY-107633 | A 1120 | 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | NCGC00370977-01 | BDBM50019040 | 2T1 | A1120 | A-1120 | CWB78219 | 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido) benzoic acid | AKOS Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms High affinity retinol-binding protein 4 (RBP4) ligand (Ki= 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious asfenretinide in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of retinol binding protein 4
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid INCHI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) InChi Key MEAQCLPMSVEOQF-UHFFFAOYSA-N Canonical SMILES C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O Isomeric SMILES C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O PubChem CID 25138295 Molecular Weight 392.37
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 39.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.81, Max Conc. mM: 25
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
H317: May cause an allergic skin reaction
H400: Very toxic to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
References 1. Wang Y, Connors R, Fan P, Wang X, Wang Z, Liu J, Kayser F, Medina JC, Johnstone S, Xu H et al. . (2014) Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.. Bioorg Med Chem Lett, 24 (13): (2885-91). [PMID:24835984 ]
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H2205672