The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
A 1120 - 98%, high purity , CAS No.1152782-19-8, Inhibitor of retinol binding protein 4
High affinity retinol-binding protein 4 (RBP4) ligand
Basic Description Synonyms GTPL8792 | HY-107633 | A 1120 | 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid | NCGC00370977-01 | BDBM50019040 | 2T1 | A1120 | A-1120 | CWB78219 | 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido) benzoic acid | AKOS Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms High affinity retinol-binding protein 4 (RBP4) ligand (Ki= 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious asfenretinide in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of retinol binding protein 4
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid INCHI InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) InChi Key MEAQCLPMSVEOQF-UHFFFAOYSA-N Canonical SMILES C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O Isomeric SMILES C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O PubChem CID 25138295 Molecular Weight 392.37
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 39.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.81, Max Conc. mM: 25
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
H317: May cause an allergic skin reaction
H400: Very toxic to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
References 1. Wang Y, Connors R, Fan P, Wang X, Wang Z, Liu J, Kayser F, Medina JC, Johnstone S, Xu H et al. . (2014) Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.. Bioorg Med Chem Lett, 24 (13): (2885-91). [PMID:24835984 ] [10.1021/op500134e ]
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
H2205672