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A 1120 - 98%, high purity , CAS No.1152782-19-8, Inhibitor of retinol binding protein 4

Moligand™
≥98%

CAS#: 1152782-19-8
Formula: C₂₀H₁₉F₃N₂O₃
Molecular Weight: 392.37
PubChem CID: 25138295

Item Number

A288923

Grouped product items
SKU	Size	Availability	Price
A288923-10mg	10mg	In stock	$177.90
A288923-50mg	50mg	In stock	$642.90
A288923-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,157.90
A288923-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,604.90

High affinity retinol-binding protein 4 (RBP4) ligand

View related series

retinol binding protein 4 Inhibitor

Basic Description

Synonyms	A 1120\|1152782-19-8\|2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid\|A-1120\|A1120\|2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid\|CHEMBL1230001\|2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	High affinity retinol-binding protein 4 (RBP4) ligand (Ki= 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious asfenretinide in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of retinol binding protein 4

Associated Targets

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RBP4 Tchem Retinol-binding protein 4 8 Activities

Discover Target: RBP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[[4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl]amino]benzoic acid
INCHI	InChI=1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)
InChi Key	MEAQCLPMSVEOQF-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O
Isomeric SMILES	C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O
PubChem CID	25138295
Molecular Weight	392.37

PubChem CID

ChEMBL Ligand

CAS Registry No.

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2205672	Certificate of Analysis	Jun 13, 2022	A288923
H2205673	Certificate of Analysis	Jun 13, 2022	A288923
H2205674	Certificate of Analysis	Jun 13, 2022	A288923
H2205675	Certificate of Analysis	Jun 13, 2022	A288923

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H302:Harmful if swallowed H317:May cause an allergic skin reaction H400:Very toxic to aquatic life
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help.

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