A-1331852 - ≥98%, high purity , CAS No.1430844-80-6, Inhibitor of Bcl-2-like 1

Item Number
A275493
Grouped product items
SKUSizeAvailabilityPrice Qty
A275493-5mg
5mg
In stock
$141.90
A275493-10mg
10mg
In stock
$224.90
A275493-25mg
25mg
In stock
$462.90
A275493-50mg
50mg
In stock
$735.90
A275493-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,305.90

Potent, selective BCL-X L inhibitor

View related series
Bcl-2-like 1 Inhibitor

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent, selective\xa0BCL-X L inhibitor (K i L-BIM complexes and induces the hallmarks of apoptosis in BCL-X L -dependent Molt-4 cells.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of Bcl-2-like 1
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

Associated Targets(Human)

BCL2 Tclin Apoptosis regulator Bcl-2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BCL2L1 Tchem Bcl-2-like protein 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOLT-4 (49676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCL2L1 Tchem Apoptosis regulator Bcl-X (2604 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCL2 Tclin Apoptosis regulator Bcl-2 (3787 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RS4-11 (1012 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 3-[1-(1-adamantylmethyl)-5-methylpyrazol-4-yl]-6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]pyridine-2-carboxylic acid
INCHI InChI=1S/C38H38N6O3S/c1-22-29(19-39-44(22)21-38-16-23-13-24(17-38)15-25(14-23)18-38)27-9-10-33(41-34(27)36(46)47)43-12-11-26-5-4-6-28(30(26)20-43)35(45)42-37-40-31-7-2-3-8-32(31)48-37/h2-10,19,23-25H,11-18,20-21H2,1H3,(H,46,47)(H,40,42,45)
InChi Key QCQQONWEDCOTBV-UHFFFAOYSA-N
Canonical SMILES CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=C(C6)C(=CC=C7)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O
Isomeric SMILES CC1=C(C=NN1CC23CC4CC(C2)CC(C4)C3)C5=C(N=C(C=C5)N6CCC7=C(C6)C(=CC=C7)C(=O)NC8=NC9=CC=CC=C9S8)C(=O)O
PubChem CID 71565985
Molecular Weight 658.81

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
A2205162Certificate of AnalysisOct 20, 2022 A275493
A2205163Certificate of AnalysisOct 20, 2022 A275493
A2205165Certificate of AnalysisOct 20, 2022 A275493
A2205169Certificate of AnalysisOct 20, 2022 A275493
A2205170Certificate of AnalysisOct 20, 2022 A275493

Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM

Related Documents

Solution Calculators