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A 1899 - ≥98%(HPLC), high purity , CAS No.498577-46-1

≥98%(HPLC)

CAS#: 498577-46-1
Formula: C₃₀H₂₆F₂N₂O₃
Molecular Weight: 500.55
PubChem CID: 9827303
PubChem SID: 488196335

Item Number

A288648

Grouped product items
SKU	Size	Availability	Price
A288648-5mg	5mg	In stock	$84.90
A288648-10mg	10mg	In stock	$152.90
A288648-25mg	25mg	In stock	$331.90
A288648-50mg	50mg	In stock	$596.90
A288648-100mg	100mg	In stock	$1,074.90

Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker

Basic Description

Synonyms	N-[(2,4-Difluorophenyl)methyl]-2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl][1,1'-biphenyl]-2-carboxamide；A1899; S 20951;S-20951;S20951;A-1899
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+channels (IC50= 0.9 μM for K2P1
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

KCNK17 Tchem Potassium channel subfamily K member 17 (1 Activities)

Discover Target: KCNK17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK3 Tclin Potassium channel subfamily K member 3 (3 Activities)

Discover Target: KCNK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK9 Tclin Potassium channel subfamily K member 9 (2 Activities)

Discover Target: KCNK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNA5 Tclin Potassium voltage-gated channel subfamily A member 5 (1 Activities)

Discover Target: KCNA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNA5 Tclin Voltage-gated potassium channel subunit Kv1.5 (1353 Activities)

Discover Target: KCNA5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK5 Tchem Potassium channel subfamily K member 5 (4 Activities)

Discover Target: KCNK5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNK17 Tchem Potassium channel subfamily K member 17 (2 Activities)

Discover Target: KCNK17

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Kcnk3 Potassium channel subfamily K member 3 (21 Activities)

Discover Target: Kcnk3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Kcnk9 Potassium channel subfamily K member 9 (8 Activities)

Discover Target: Kcnk9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488196335
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488196335
IUPAC Name	N-[(2,4-difluorophenyl)methyl]-2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzamide
INCHI	InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
InChi Key	IXKPEYHRIVQTCU-UHFFFAOYSA-N
Canonical SMILES	COC1=CC=C(C=C1)CC(=O)NCC2=CC=CC=C2C3=CC=CC=C3C(=O)NCC4=C(C=C(C=C4)F)F
Isomeric SMILES	COC1=CC=C(C=C1)CC(=O)NCC2=CC=CC=C2C3=CC=CC=C3C(=O)NCC4=C(C=C(C=C4)F)F
PubChem CID	9827303
Molecular Weight	500.55

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10 results found

Lot Number	Certificate Type	Date	Item
C2321156	Certificate of Analysis	Feb 18, 2023	A288648
C2321176	Certificate of Analysis	Feb 18, 2023	A288648
C2321177	Certificate of Analysis	Feb 18, 2023	A288648
C2321185	Certificate of Analysis	Feb 18, 2023	A288648
C2321190	Certificate of Analysis	Feb 18, 2023	A288648
C2321192	Certificate of Analysis	Feb 18, 2023	A288648
C2321200	Certificate of Analysis	Feb 18, 2023	A288648
C2321203	Certificate of Analysis	Feb 18, 2023	A288648
C2321233	Certificate of Analysis	Feb 18, 2023	A288648
C2321237	Certificate of Analysis	Feb 18, 2023	A288648

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