Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A288284-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $83.90 | |
A288284-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $132.90 | |
A288284-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $266.90 | |
A288284-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $444.90 | |
A288284-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $801.90 |
Potent inhibitor of the LFA-1/ICAM-1 interaction
Synonyms | 280749-17-9|A-286982|A 286982|A286982|(E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one|CHEMBL19677|5I8WFS075A|2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-(4-((2-(1-methylethyl)phenyl)thio)-3-nitrophenyl)-|(2 |
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Specifications & Purity | 98% |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of integrin αLβ2 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one |
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INCHI | InChI=1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+ |
InChi Key | HTGGAYLWTDOFDK-PKNBQFBNSA-N |
Canonical SMILES | CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)C=CC(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-] |
Isomeric SMILES | CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)/C=C/C(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-] |
PubChem CID | 9846729 |
Molecular Weight | 453.55 |
CAS Registry No. | 280749-17-9 |
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PubChem CID | 9846729 |
ChEMBL Ligand | CHEMBL19677 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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J2112126 | Certificate of Analysis | Jul 19, 2024 | A288284 |
J2112127 | Certificate of Analysis | Jul 19, 2024 | A288284 |
J2112128 | Certificate of Analysis | Jul 19, 2024 | A288284 |
J2112129 | Certificate of Analysis | Jul 19, 2024 | A288284 |
J2112130 | Certificate of Analysis | Jul 19, 2024 | A288284 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 45.35, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 22.68, Max Conc. mM: 50;DMF: 30 mg/ml |
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1. Liu G, Link JT, Pei Z, Reilly EB, Leitza S, Nguyen B, Marsh KC, Okasinski GF, von Geldern TW, Ormes M et al.. (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.. J Med Chem, 43 (21): (4025-40). [PMID:11052808] |