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A 286982 - 98%, high purity , CAS No.280749-17-9, Inhibitor of integrin αLβ2

Moligand™

≥98%

CAS#: 280749-17-9
Formula: C₂₄H₂₇N₃O₄S
Molecular Weight: 453.55
PubChem CID: 9846729

Item Number

A288284

Grouped product items
SKU	Size	Availability	Price
A288284-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$83.90
A288284-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$132.90
A288284-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$266.90
A288284-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90
A288284-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$801.90

Potent inhibitor of the LFA-1/ICAM-1 interaction

View related series

integrin αLβ2 Inhibitor

Basic Description

Synonyms	A286982 \| A899560 \| UNII-5I8WFS075A \| BDBM50092956 \| F77491 \| A 286,982 \| (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one \| A286982 \| A-286982 \| cid_108661 \| GTPL6592 \| A 286982 \| 1-(4-Acetyl-piperazin-1-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent inhibitor of the LFA-1/ICAM-1 interaction (IC50values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).Lymphocyte function-associated antigen-1 (LFA-1) is a member of the leukocyte integrin family, whic
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of integrin αLβ2

Associated Targets(Human)

ITGB2 Tclin Integrin beta-2 (0 Activities)

Discover Target: ITGB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ICAM1 Tchem Intercellular adhesion molecule 1 (1 Activities)

Discover Target: ICAM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGAL Tclin Integrin alpha-L (1 Activities)

Discover Target: ITGAL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGAL Tclin Leukocyte adhesion glycoprotein LFA-1 alpha (170 Activities)

Discover Target: ITGAL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ICAM1 Tchem Intercellular adhesion molecule-1 (260 Activities)

Discover Target: ICAM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGAL Tclin Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 (760 Activities)

Discover Target: ITGAL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one
INCHI	InChI=1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+
InChi Key	HTGGAYLWTDOFDK-PKNBQFBNSA-N
Canonical SMILES	CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)C=CC(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-]
Isomeric SMILES	CC(C)C1=CC=CC=C1SC2=C(C=C(C=C2)/C=C/C(=O)N3CCN(CC3)C(=O)C)[N+](=O)[O-]
PubChem CID	9846729
Molecular Weight	453.55

CAS Registry No.

280749-17-9

PubChem CID

9846729

ChEMBL Ligand

CHEMBL19677

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
J2112126	Certificate of Analysis	Jul 19, 2024	A288284
J2112127	Certificate of Analysis	Jul 19, 2024	A288284
J2112128	Certificate of Analysis	Jul 19, 2024	A288284
J2112129	Certificate of Analysis	Jul 19, 2024	A288284
J2112130	Certificate of Analysis	Jul 19, 2024	A288284

References

1. Liu G, Link JT, Pei Z, Reilly EB, Leitza S, Nguyen B, Marsh KC, Okasinski GF, von Geldern TW, Ormes M et al.. (2000) Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.. J Med Chem, 43 (21): (4025-40). [PMID:11052808]

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A 286982 - 98%, high purity , CAS No.280749-17-9, Inhibitor of integrin αLβ2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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