A-412997 dihydrochloride - ≥98%, high purity , CAS No.630116-49-3, Agonist of D 4 receptor

Item Number
A274865
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A274865-1mg
1mg
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$139.90
A274865-5mg
5mg
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$419.90
A274865-10mg
10mg
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$659.90
A274865-25mg
25mg
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$1,329.90
A274865-50mg
50mg
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$1,979.90

Highly selective D 4 agonist

View related series
D4 receptor Agonist

Basic Description

SynonymsSCHEMBL4010266 | 2-(3'',4'',-5'',6''-tetrahydro-2''H-[2,4''-bipyridine]-1''-yl)-N-(m-tolyl)acetamide | DTXSID70212234 | Q4646874 | N-(3-methylphenyl)-4-(2-pyridinyl)-1-Piperidineacetamide | XDC74496 | UNII-RWL9H93ARB | GTPL3301 | 2-(4-(pyridin-2-yl)piperi
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsHighly selective dopamine D 4 receptor agonist at rat D 4 and human D 4.4 receptors (K i values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D 4 receptors (EC 50 = 28.4 nM).
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of D 4 receptor

Associated Targets(Human)

DRD4 Tchem D(4) dopamine receptor (8 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD5 Tchem Dopamine D5 receptor (1597 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T98G (1524 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine receptors; D3 & D4 (312 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
INCHI InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)
InChi Key JFCDMGGMCUKHST-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=CC=C1)NC(=O)CN2CCC(CC2)C3=CC=CC=N3
Isomeric SMILES CC1=CC(=CC=C1)NC(=O)CN2CCC(CC2)C3=CC=CC=N3
Alternate CAS 1347744-96-0
PubChem CID 10425450
Molecular Weight 309.41

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in water to 100 mM

Related Documents

Solution Calculators