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A-443654 - ≥98.0%, high purity , CAS No.552325-16-3, Inhibitor of AKT serine/threonine kinase 1;Inhibitor of AKT serine/threonine kinase 2;Inhibitor of AKT serine/threonine kinase 3;Inhibitor of CDC42 binding protein kinase beta;Inhibitor of phosphorylase kinase catalytic subunit gamma 1

  • Moligand™
  • ≥98%
Item Number
A126060
Grouped product items
SKUSizeAvailabilityPrice Qty
A126060-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$169.90
A126060-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$269.90
A126060-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$539.90
A126060-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$869.90
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AKT serine/threonine kinase 1 Inhibitor AKT serine/threonine kinase 2 Inhibitor AKT serine/threonine kinase 3 Inhibitor CDC42 binding protein kinase beta Inhibitor phosphorylase kinase catalytic subunit gamma 1 Inhibitor

Basic Description

SynonymsA-443654|552325-16-3|A 443654|(2s)-1-(1h-Indol-3-Yl)-3-{[5-(3-Methyl-1h-Indazol-5-Yl)pyridin-3-Yl]oxy}propan-2-Amine|A443654|(2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine|(S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indaz
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsA-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of AKT serine/threonine kinase 1;Inhibitor of AKT serine/threonine kinase 2;Inhibitor of AKT serine/threonine kinase 3;Inhibitor of CDC42 binding protein kinase beta;Inhibitor of phosphorylase kinase catalytic subunit gamma 1
Product Description

A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines.

Names and Identifiers

IUPAC Name (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan-2-amine
INCHI InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
InChi Key YWTBGJGMTBHQTM-IBGZPJMESA-N
Canonical SMILES CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OCC(CC4=CNC5=CC=CC=C54)N
Isomeric SMILES CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CNC5=CC=CC=C54)N
PubChem CID 10172943
Molecular Weight 397.48

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8 results found

Lot NumberCertificate TypeDateItem
H2406300Certificate of AnalysisMay 07, 2024 A126060
H2406301Certificate of AnalysisMay 07, 2024 A126060
H2406319Certificate of AnalysisMay 07, 2024 A126060
H2406320Certificate of AnalysisMay 07, 2024 A126060
H2406321Certificate of AnalysisMay 07, 2024 A126060
H2406326Certificate of AnalysisMay 07, 2024 A126060
H2406334Certificate of AnalysisMay 07, 2024 A126060
H2406335Certificate of AnalysisMay 07, 2024 A126060

Chemical and Physical Properties

Solubilityinsoluble in H2O；≥19.85 mg/mL in DMSO；≥44.3 mg/mL in EtOH

Related Documents

 SDS

 Specification Sheet

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References

1. Luo Y, Shoemaker AR, Liu X, Woods KW, Thomas SA, de Jong R, Han EK, Li T, Stoll VS, Powlas JA et al..  (2005)  Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo..  Mol Cancer Ther,  4  (6): (977-86).  [PMID:15956255]
2. Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, Giranda VL, Luo Y.  (2007)  Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition..  Oncogene,  26  (38): (5655-61).  [PMID:17334390]
3. Okuzumi T, Fiedler D, Zhang C, Gray DC, Aizenstein B, Hoffman R, Shokat KM.  (2009)  Inhibitor hijacking of Akt activation..  Nat Chem Biol,  5  (7): (484-93).  [PMID:19465931]

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