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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A287597-5mg | 5mg | In stock | $164.90 | |
A287597-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $229.90 | |
A287597-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $399.90 | |
A287597-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $549.90 | |
A287597-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $989.90 |
Potent and selective p300/CBP inhibitor
Synonyms | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide; A-485;N-(4-fluorobenzyl)-2-((R)-5-(3-methylureido)-2′,4′-dioxo-2,3-dihydrospiro[ |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Highly potent and selective inhibitor of the HAT domain of p300/CREB-binding protein (CBP) (IC50 values of CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains are 2.6 and 9.8 nM, respectively). Shows >1000-fold selectivity on closely related HATs. Inhib |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively. |
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IUPAC Name | N-[(4-fluorophenyl)methyl]-2-[(3R)-6-(methylcarbamoylamino)-2',4'-dioxospiro[1,2-dihydroindene-3,5'-1,3-oxazolidine]-3'-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide |
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INCHI | InChI=1S/C25H24F4N4O5/c1-14(25(27,28)29)32(12-15-3-5-17(26)6-4-15)20(34)13-33-21(35)24(38-23(33)37)10-9-16-11-18(7-8-19(16)24)31-22(36)30-2/h3-8,11,14H,9-10,12-13H2,1-2H3,(H2,30,31,36)/t14-,24+/m0/s1 |
InChi Key | VRVJKILQRBSEAG-LFPIHBKWSA-N |
Canonical SMILES | CC(C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)C3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O |
Isomeric SMILES | C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC)OC2=O |
PubChem CID | 118958122 |
Molecular Weight | 536.48 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2420358 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420362 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420425 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420435 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420436 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420439 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420458 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420473 | Certificate of Analysis | May 21, 2024 | A287597 |
F2420492 | Certificate of Analysis | May 21, 2024 | A287597 |
C2411063 | Certificate of Analysis | Jun 30, 2022 | A287597 |
G2304380 | Certificate of Analysis | Jun 30, 2022 | A287597 |
I2206119 | Certificate of Analysis | Jun 30, 2022 | A287597 |
I2206120 | Certificate of Analysis | Jun 30, 2022 | A287597 |
I2206121 | Certificate of Analysis | Jun 30, 2022 | A287597 |
I2206122 | Certificate of Analysis | Jun 30, 2022 | A287597 |
I2206123 | Certificate of Analysis | Jun 30, 2022 | A287597 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 53.65, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 53.65, Max Conc. mM: 100 |
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