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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A275405-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $629.90 |
Potent, selective α 1A -adrenoceptor agonist
Synonyms | AKOS024456352 | N-(5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)methanesulfonamide hydrobromide | CS-0021226 | SR-01000597927 | N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-methanesulfona |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Potent, selective α 1A -adrenoceptor agonist. Increases spontaneous Ca 2+ transients in myocytes (EC 50 = 7 nM). Shows vasoconstrictive and hypertensive effects in vivo. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Application: A-61603 is a selective agonist of α 1A -adrenergic receptor ;A-61603 increases the frequency of spontaneous Ca 2+ transients in rat ventricular myocytes in vitro . |
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IUPAC Name | N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide;hydrobromide |
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INCHI | InChI=1S/C14H19N3O3S.BrH/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18;/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16);1H |
InChi Key | LRFLWCZMTGTUEP-UHFFFAOYSA-N |
Canonical SMILES | CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O.Br |
Isomeric SMILES | CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O.Br |
PubChem CID | 9865178 |
Molecular Weight | 389.31 |
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Solubility | Soluble in water to 10 mM, in ethanol to 10mM and in DMSO to 100mM;DMF: 20 mg/ml; DMSO: 20 mg/ml; ethanol: 1 mg/ml; PBS (pH 7.2) : 10 mg/ml |
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Flash Point(°C) | 285.5°C |
Boil Point(°C) | 548.4°C |