| 1. Cool B, Zinker B, Chiou W, Kifle L, Cao N, Perham M, Dickinson R, Adler A, Gagne G, Iyengar R et al.. (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.. Cell Metab, 3 (6): (403-16). [PMID:16753576] [10.1021/op500134e] |
| 2. Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling D. (2007) Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.. J Biol Chem, 282 (45): (32539-48). [PMID:17728241] [10.1021/op500134e] |
| 3. Göransson O, McBride A, Hawley SA, Ross FA, Shpiro N, Foretz M, Viollet B, Hardie DG, Sakamoto K. (2007) Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.. J Biol Chem, 282 (45): (32549-60). [PMID:17855357] [10.1021/op500134e] |
| 4. Walter C, Clemens LE, Müller AJ, Fallier-Becker P, Proikas-Cezanne T, Riess O, Metzger S, Nguyen HP. (2016) Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro.. Neuropharmacology, 108 (13): (24-38). [PMID:27133377] [10.1021/op500134e] |
| 5. Webb TJ et al.. (2016) Alterations in cellular metabolism modulate CD1d-mediated NKT-cell responses.. Pathog Dis, 74 (6): [PMID:27297969] |
| 6. Choudhury Y et al.. (2014) AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.. Oncoscience, 1 (6): (446-56). [PMID:25594043] |
| 7. Qin Y et al.. (2019) AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression.. Mol Oncol, 13 (6): (1419-1432). [PMID:31033201] |
| 8. Shrikanth CB et al.. (2021) AMPK differentially alters sulphated glycosaminoglycans under normal and high glucose milieu in proximal tubular cells.. J Biochem, 169 (75-86). [PMID:32785657] |
| 9. Watterson KR et al.. (2013) Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.. Neurosignals, 21 (1-2): (28-41). [PMID:22456226] |
| 10. Head SA et al.. (2015) Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.. Proc Natl Acad Sci U S A, 112 (52): (E7276-85). [PMID:26655341] |
| 11. Henry WS et al.. (2017) Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling.. Cancer Res, 77 (3): (790-801). [PMID:27940576] |
| 12. Mancini SJ et al.. (2018) Canagliflozin inhibits interleukin-1ß-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.. Sci Rep, 8 (5276). [PMID:29588466] |
| 13. Bizjak M et al.. (2017) Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.. Sci Rep, 7 (1761). [PMID:28496098] |
| 14. Schiavon CR et al.. (2018) Compositional complexity of rods and rings.. Mol Biol Cell, 29 (19): (2303-2316). [PMID:30024290] |
| 15. Vincent EE et al.. (2014) Differential effects of AMPK agonists on cell growth and metabolism.. Oncogene, [PMID:25241895] |
| 16. Zibrova D et al.. (2017) GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.. Biochem J, 474 (6): (983-1001). [PMID:28008135] |
| 17. Galic S et al.. (2011) Hematopoietic AMPK ß1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity.. J Clin Invest, 121 (12): (4903-15). [PMID:22080866] |
| 18. Gao Y et al.. (2020) LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate.. Gastroenterology, 158 (5): (1389-1401.e10). [PMID:31930988] |
| 19. Ren Y et al.. (2021) Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation.. Free Radic Biol Med, 166 (128-139). [PMID:33636336] |
| 20. Chen Z et al.. (2012) Promotion of adiponectin multimerization by emodin, a novel AMPK activator with PPAR?-agonist activity.. J Cell Biochem, [PMID:22730200] |
| 21. Langendorf CG et al.. (2016) Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.. Nat Commun, 7 (10912). [PMID:26952388] |
| 22. Ngoei KRW et al.. (2018) Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK a2ß2?1 by the Glucose Importagog SC4.. Cell Chem Biol, 25 (6): (728-737.e9). [PMID:29657085] |
| 23. Yan Y et al.. (2015) SUMOylation of AMPKa1 by PIAS4 specifically regulates mTORC1 signalling.. Nat Commun, 6 (8979). [PMID:26616021] |
| 24. Dite TA et al.. (2017) The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.. Nat Commun, 8 (571). [PMID:28924239] |
E1620039