A-803467 - ≥98%, high purity , CAS No.944261-79-4, Channel blocker of Na v1.8

Item Number

A127941

• Synonyms: MFCD10574689 | 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide | AS-55982 | N-t-butoxycarbonyl-S-tritylcysteine | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)- 2-furancarboxamide. | BCP9000209 | HMS3656L08 | EX-A083 | AB07953 | EC-000.2378 | SMR004702
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC50 of 8 nM and IC50 of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.Selective blocker of Na V 1.8 channels (IC 50 = 8 nM
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: CHANNEL BLOCKER
• Mechanism of action: Channel blocker of Na v1.8
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

 A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects.A-803467 decreases the firing in spinal dorsal horn neurons in vivo.

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models.A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic