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A 841720 - ≥98%, high purity , CAS No.869802-58-4, Allosteric modulator of mGlu 1 receptor
a potent & non-competitive mGluR-1 antagonist
Basic Description Synonyms BDBM50177080 | 9-dimethylamino-3-(N-hexamethyleneiminyl)-3H-5-thia-1,3,6-triazafluoren-4-one | 9-(DIMETHYLAMINO)-3-(HEXAHYDRO-1H-AZEPIN-1-YL)PYRIDO[3' ,2':4,5]THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE | DTXSID10236030 | A-440 | UNII-U8C5C9D65S | AKOS024457407 | A Specifications & Purity Moligand™, ≥98% Storage Temp Room temperature Shipped In Normal Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of mGlu 1 receptor Product Description
A 841720 is a potent, non-competitive mGluR-1 antagonist that displays 34-fold selectivity over mGluR-5 (IC|50|values are 10 and 342 nM respectively). A 841720 displays no significant activity at a range of other GPCRs, ion channels and transporters. This compound also exhibits analgesic effects, decreases mechanical allodynia in models of neuropathic pain, and impairs cognitive function.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens
Names and Identifiers IUPAC Name 5-(azepan-1-yl)-13-(dimethylamino)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one INCHI InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3 InChi Key GYWGXEGOXODOQU-UHFFFAOYSA-N Canonical SMILES CN(C)C1=C2C3=C(C(=O)N(C=N3)N4CCCCCC4)SC2=NC=C1 Isomeric SMILES CN(C)C1=C2C3=C(C(=O)N(C=N3)N4CCCCCC4)SC2=NC=C1 PubChem CID 11559235 Molecular Weight 343.45
Chemical and Physical Properties Solubility Soluble to 50 mM in DMSO and to 50 mM in Ethanol
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