| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| E194035-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $92.90 | |
| E194035-250mg | 250mg | 2 | $97.90 | |
| E194035-1g | 1g | 3 | $241.90 | |
| E194035-5g | 5g | 3 | $756.90 |
Endogenous estrogen receptor agonist
| Synonyms | CCRIS 7203 | Estra-1,3,5(10)-triene-3,17alpha-diol | NCGC00161666-02 | Alfatradiol;Epiestradiol;Epiestrol | LMST02010029 | Oestra-1,3,5(10)-triene-3,17alpha-diol | 17.alpha.-Estradiol | 17alpha-E2 | Alfatradiol | alpha-Estradiol, powder, >=98% (TLC) | Oes |
|---|---|
| Specifications & Purity | Moligand™, ≥98% |
| Biochemical and Physiological Mechanisms | Endogenous estrogen receptor ligand (Kivalues are 0.2 and 1.2 nM for ERαand ERβreceptors respectively).β-Estradiolalso available. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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| Pubchem Sid | 504754299 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504754299 |
| IUPAC Name | (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| INCHI | InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1 |
| InChi Key | VOXZDWNPVJITMN-SFFUCWETSA-N |
| Canonical SMILES | CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O |
| Isomeric SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@H]2O)CCC4=C3C=CC(=C4)O |
| WGK Germany | 3 |
| RTECS | KG3750000 |
| Alternate CAS | 57-91-0 |
| PubChem CID | 68570 |
| NSC Number | 20293 |
| MeSH Entry Terms | alfatradiol |
| Molecular Weight | 272.39 |
Find and download the COA for your product by matching the lot number on the packaging.
6 results found
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 H2212411 | Certificate of Analysis | Jul 23, 2022 | E194035 |
| H2212412 | Certificate of Analysis | Jul 23, 2022 | E194035 |
| H2212447 | Certificate of Analysis | Jul 23, 2022 | E194035 |
| J2424320 | Certificate of Analysis | Jul 23, 2022 | E194035 |
| K2301081 | Certificate of Analysis | Jul 23, 2022 | E194035 |
| B2217105 | Certificate of Analysis | Feb 21, 2022 | E194035 |
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 27.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 27.24, Max Conc. mM: 100 |
|---|---|
| Specific Rotation[α] | +46.0 to +52.0 deg(C=1, Dioxane) |
| Melt Point(°C) | 222.0 - 226.0 °C |
| Molecular Weight | 272.400 g/mol |
| XLogP3 | 4.000 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 0 |
| Exact Mass | 272.178 Da |
| Monoisotopic Mass | 272.178 Da |
| Topological Polar Surface Area | 40.500 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 382.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H362:May cause harm to breast-fed children |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
| WGK Germany | 3 |
| RTECS | KG3750000 |
| 1. Xian Liu, Like Chen, Yang Yang, Liping Xu, Junyong Sun, Tian Gan. (2023) MXene−reinforced octahedral PtCu nanocages with boosted electrocatalytic performance towards endocrine disrupting pollutants sensing. JOURNAL OF HAZARDOUS MATERIALS, 442 (130000). [PMID:36137886] [10.1016/j.jhazmat.2022.130000] |
| 2. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] [10.1016/j.aca.2022.340270] |
| 3. Xianze Wang, Zhongmou Liu, Zhian Ying, Mingxin Huo, Wu Yang. (2018) Adsorption of Trace Estrogens in Ultrapure and Wastewater Treatment Plant Effluent by Magnetic Graphene Oxide. International Journal of Environmental Research and Public Health, 15 (7): (1454). [PMID:29996530] [10.3390/ijerph15071454] |
| 4. Hailong Peng, Mei Luo, Hua Xiong, Ningxiang Yu, Fangjian Ning, Jieping Fan, Zheling Zeng, Jinhua Li, Lingxin Chen. (2016) Preparation of photonic-magnetic responsive molecularly imprinted microspheres and their application to fast and selective extraction of 17β-estradiol. JOURNAL OF CHROMATOGRAPHY A, 1442 (1). [PMID:27000739] [10.1016/j.chroma.2016.03.003] |
| 5. Fangjian Ning, Hailong Peng, Jinhua Li, Lingxin Chen, Hua Xiong. (2014) Molecularly Imprinted Polymer on Magnetic Graphene Oxide for Fast and Selective Extraction of 17β-Estradiol. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62 (30): (7436–7443). [PMID:25017481] [10.1021/jf501845w] |
| 6. Xiaoxiao Wang,Huachun Liu,Zhian Sun,Shanwen Zhao,Yanqiang Zhou,Jianmin Li,Tianpei Cai,Bolin Gong. (2020-06-25) Monodisperse restricted access material with molecularly imprinted surface for selective solid-phase extraction of 17β-estradiol from milk.. Journal of separation science, 43 ((17)): (3520-3533). [PMID:32579267] |
| 7. Bing Wang,Huanxiang Yuan,Chunlei Zhu,Qiong Yang,Fengting Lv,Libing Liu,Shu Wang. (2012-10-26) Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells.. Scientific reports, 2 (766-766). [PMID:23097688] |
| 1. Xian Liu, Like Chen, Yang Yang, Liping Xu, Junyong Sun, Tian Gan. (2023) MXene−reinforced octahedral PtCu nanocages with boosted electrocatalytic performance towards endocrine disrupting pollutants sensing. JOURNAL OF HAZARDOUS MATERIALS, 442 (130000). [PMID:36137886] [10.1016/j.jhazmat.2022.130000] |
| 2. Yanqun Yang, Yipeng Huang, Zhuqiang Wu, Rui Shi, Zhengyi Chen, Guihua Ruan. (2022) Porous capillary monolithic column coupled with ultrahigh performance liquid chromatography-tandem mass spectrometry for fast and effective separation and determination of estrogens. ANALYTICA CHIMICA ACTA, 1227 (340270). [PMID:36089309] [10.1016/j.aca.2022.340270] |
| 3. Xianze Wang, Zhongmou Liu, Zhian Ying, Mingxin Huo, Wu Yang. (2018) Adsorption of Trace Estrogens in Ultrapure and Wastewater Treatment Plant Effluent by Magnetic Graphene Oxide. International Journal of Environmental Research and Public Health, 15 (7): (1454). [PMID:29996530] [10.3390/ijerph15071454] |
| 4. Hailong Peng, Mei Luo, Hua Xiong, Ningxiang Yu, Fangjian Ning, Jieping Fan, Zheling Zeng, Jinhua Li, Lingxin Chen. (2016) Preparation of photonic-magnetic responsive molecularly imprinted microspheres and their application to fast and selective extraction of 17β-estradiol. JOURNAL OF CHROMATOGRAPHY A, 1442 (1). [PMID:27000739] [10.1016/j.chroma.2016.03.003] |
| 5. Fangjian Ning, Hailong Peng, Jinhua Li, Lingxin Chen, Hua Xiong. (2014) Molecularly Imprinted Polymer on Magnetic Graphene Oxide for Fast and Selective Extraction of 17β-Estradiol. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 62 (30): (7436–7443). [PMID:25017481] [10.1021/jf501845w] |
| 6. Xiaoxiao Wang,Huachun Liu,Zhian Sun,Shanwen Zhao,Yanqiang Zhou,Jianmin Li,Tianpei Cai,Bolin Gong. (2020-06-25) Monodisperse restricted access material with molecularly imprinted surface for selective solid-phase extraction of 17β-estradiol from milk.. Journal of separation science, 43 ((17)): (3520-3533). [PMID:32579267] |
| 7. Bing Wang,Huanxiang Yuan,Chunlei Zhu,Qiong Yang,Fengting Lv,Libing Liu,Shu Wang. (2012-10-26) Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells.. Scientific reports, 2 (766-766). [PMID:23097688] |
