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(±)-α-Methyl-(4-carboxyphenyl)glycine - 95%, high purity , CAS No.146669-29-6

  • ≥95%
Item Number
M274690
Grouped product items
SKUSizeAvailabilityPrice Qty
M274690-1mg
1mg
In stock
$36.90
M274690-5mg
5mg
In stock
$78.90
M274690-10mg
10mg
In stock
$107.90
M274690-25mg
25mg
In stock
$236.90
M274690-50mg
50mg
In stock
$424.90
M274690-100mg
100mg
In stock
$771.90
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Group I /II metabotropic glutamate antagonist

Basic Description

SynonymsAKOS005066801 | ( inverted question mark)-MCPG | ( inverted exclamation markA)-MCPG | (RS)-.ALPHA.-METHYL-4-CARBOXYPHENYLGLYCINE | HB0037 | LP00747 | (+/-)-.ALPHA.-METHYL-4-CARBOXYPHENYLGLYCINE | J-008240 | (y)-alpha-Methyl-4-carboxyphenylglycine | CS-570
Specifications & Purity≥95%
Biochemical and Physiological Mechanisms(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks TBS-induced transition in juvenile and neonatal rat hippocampal neurons.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FEN1 Tchem Flap endonuclease 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLCB1 Tbio 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RGS4 Tchem Regulator of G-protein signaling 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LMNA Tbio Prelamin-A/C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BLM Tchem Bloom syndrome protein (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ARSA Tbio Arylsulfatase A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM1 Tchem Metabotropic glutamate receptor 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM2 Tchem Metabotropic glutamate receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM4 Tchem Metabotropic glutamate receptor 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM5 Tchem Metabotropic glutamate receptor 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM3 Tchem Metabotropic glutamate receptor 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM6 Tchem Metabotropic glutamate receptor 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GRM3 Tchem Metabotropic glutamate receptor 3 (732 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM4 Tchem Metabotropic glutamate receptor 4 (2320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM6 Tchem Metabotropic glutamate receptor 6 (361 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM1 Tchem Metabotropic glutamate receptor 1 (2309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRM5 Tchem Metabotropic glutamate receptor 5 (5733 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLCB1 Tbio Phospholipase C-beta-1 (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Grm2 Metabotropic glutamate receptor 2 (1326 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-(1-amino-1-carboxyethyl)benzoic acid
INCHI InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
InChi Key DNCAZYRLRMTVSF-UHFFFAOYSA-N
Canonical SMILES CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
Isomeric SMILES CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
PubChem CID 1222
Molecular Weight 209.2

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
K2212531Certificate of AnalysisAug 17, 2023 M274690
K2212532Certificate of AnalysisAug 17, 2023 M274690
K2212534Certificate of AnalysisAug 17, 2023 M274690
K2212588Certificate of AnalysisAug 17, 2023 M274690
K2212590Certificate of AnalysisAug 17, 2023 M274690
K2212530Certificate of AnalysisJun 21, 2022 M274690

Chemical and Physical Properties

SolubilitySoluble in 1 eq. NaOH to 100 mM

Related Documents

 SDS

 Specification Sheet

References

1. Bouthour W et al..  (2012)  A human mutation in Gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors..  Cereb Cortex,  22  (7): (1542-53).  [PMID:21908847]
2. Hedrick T & Waters J.  (2015)  Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors..  J Neurophysiol,  113  (7): (2195-209).  [PMID:25589590]
3. Chamma I et al..  (2013)  Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons..  J Neurosci,  33  (39): (15488-503).  [PMID:24068817]
4. Kosillo P et al..  (2016)  Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons..  Cereb Cortex,      [PMID:27566978]
5. Jo YH.  (2012)  Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus..  J Neurophysiol,  107  (42-9).  [PMID:21994261]
6. Liotta A et al..  (2012)  Energy demand of synaptic transmission at the hippocampal Schaffer-collateral synapse..  J Cereb Blood Flow Metab,  32  (11): (2076-83).  [PMID:22929439]
7. Locatelli F et al..  (2013)  Late-onset bursts evoked by mossy fibre bundle stimulation in unipolar brush cells: evidence for the involvement of H- and TRP-currents..  J Physiol,  591  (Pt 4): (899-918).  [PMID:23129798]

Solution Calculators

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