Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

Aprotinin from bovine lung - 3-8 TIU/mg, high purity , CAS No.9087-70-1, Inhibitor of plasminogen

7 Citations
Item Number
A105534
Grouped product items
SKUSizeAvailabilityPrice Qty
A105534-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$9.90
A105534-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$37.90
A105534-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$57.90
A105534-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$102.90
A105534-250mg
250mg
In stock
$232.90
A105534-500mg
500mg
In stock
$418.90
A105534-1g
1g
In stock
$754.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Competitive, reversible serine protease inhibitor.

View related series
Anti-infection Influenza Virus Metabolic Enzyme/Protease plasminogen Inhibitor Ser/Thr Protease

Basic Description

SynonymsAprotinin from bovine lung | CCG-270718 | APROTININ | Traskolan | Antilysin | J-200086 | Bovine Pancreatic Trypsin Inhibitor | AKOS024457997 | Traskolan | Bovine Pancreatic Trypsin Inhibitor
Specifications & PurityEnzymoPure™, 3-8 TIU/mg
Biochemical and Physiological MechanismsAprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Ap
Storage TempStore at 2-8°C
Shipped InWet ice
GradeEnzymoPure™
Action TypeINHIBITOR
Mechanism of actionInhibitor of plasminogen
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Aprotinin is a single chain polypeptide (58 amino-acids) crosslinked by three disulfide bridges, showing competitive and reversible inhibiton of proteolytic and esterolytic activity. Aprotinin forms stable complexes and blocks the active sites of serine protease enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3 (optimum pH 5-7); effective concentration is equimolar with protease. Used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones.
Aprotinin is largely used as an inhibitor of trypsin.

Associated Targets(Human)

PLG Tclin Plasminogen (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[[1-[[29a,62a,69,84-tetrakis(4-aminobutyl)-35a,75,78-tris(2-amino-2-oxoethyl)-14a-(3-amino-3-oxopropyl)-8a,41a,72-tribenzyl-50a,53a-di(butan-2-yl)-47a,48,56a,81,90-pentakis(3-carbamimidamidopropyl)-31,60-bis(2-carboxyethyl)-42-[[2-[[2-(1-carboxyethylamino)-2-oxoethyl]amino]-2-oxoethyl]carbamoyl]-57-(carboxymethyl)-11a,13,45-tris(1-hydroxyethyl)-66-(hydroxymethyl)-2a,16,38a,44a-tetrakis[(4-hydroxyphenyl)methyl]-26a,32a,59a,63,87-pentamethyl-20a,34-bis(2-methylpropyl)-51-(2-methylsulfanylethyl)-1a,3,4a,7a,9,10a,12,13a,15,16a,18,19a,22a,24,25a,28a,30,31a,33,34a,36,37a,40a,43a,44,46a,47,49a,50,52a,53,55a,56,58a,59,61a,62,64a,65,68,71,74,77,80,83,86,89,92,95,98-pentacontaoxo-5a-propan-2-yl-39,40,66a,67a,70a,71a-hexathia-a,2,3a,6a,8,9a,11,12a,14,15a,17,18a,21a,23,24a,27a,29,30a,32,33a,35,36a,39a,42a,43,45a,46,48a,49,51a,52,54a,55,57a,58,60a,61,63a,64,67,70,73,76,79,82,85,88,91,94,97-pentacontazahexacyclo[91.71.4.454,117.04,8.019,23.025,29]doheptacontahectan-37-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidine-2-carbonyl]amino]-4-oxobutanoic acid
INCHI InChI=1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(414)322-149(14)230(398)326-168(62-35-39-98-285)234(402)319-146(11)227(395)314-132-215(385)324-181(113-141(3)4)247(415)354-199-137-452-453-138-200-263(431)336-179(97-112-448-20)242(410)331-176(70-48-107-311-284(304)305)244(412)363-226(154(19)372)274(442)358-197(233(401)316-129-212(382)312-130-213(383)318-151(16)278(446)447)135-449-451-139-201(355-253(421)186(117-157-57-31-25-32-58-157)344-256(424)195(127-220(393)394)350-267(435)204-72-50-109-366(204)275(443)167(289)61-43-102-306-279(294)295)265(433)339-182(114-142(5)6)248(416)338-180(93-96-218(389)390)276(444)368-111-52-74-206(368)277(445)367-110-51-73-205(367)268(436)349-189(122-162-81-89-166(376)90-82-162)259(427)362-224(152(17)370)269(437)317-133-216(386)365-108-49-71-203(365)266(434)357-202(264(432)333-169(63-36-40-99-286)235(403)320-148(13)229(397)328-175(69-47-106-310-283(302)303)243(411)360-223(145(10)22-2)272(440)361-222)140-454-450-136-198(325-214(384)131-313-211(381)128-315-232(400)183(119-159-75-83-163(373)84-76-159)351-270(438)221(143(7)8)359-258(426)190(118-158-59-33-26-34-60-158)352-273(441)225(153(18)371)364-245(413)177(335-262(199)430)91-94-207(290)377)261(429)334-172(66-44-103-307-280(296)297)236(404)321-147(12)228(396)327-170(64-37-41-100-287)237(405)330-173(67-45-104-308-281(298)299)238(406)345-192(124-209(292)379)255(423)347-193(125-210(293)380)254(422)343-184(115-155-53-27-23-28-54-155)249(417)332-171(65-38-42-101-288)240(408)353-196(134-369)260(428)323-150(15)231(399)329-178(92-95-217(387)388)241(409)348-194(126-219(391)392)257(425)356-200/h23-34,53-60,75-90,141-154,167-206,221-226,369-376H,21-22,35-52,61-74,91-140,285-289H2,1-20H3,(H2,290,377)(H2,291,378)(H2,292,379)(H2,293,380)(H,312,382)(H,313,381)(H,314,395)(H,315,400)(H,316,401)(H,317,437)(H,318,383)(H,319,402)(H,320,403)(H,321,404)(H,322,414)(H,323,428)(H,324,385)(H,325,384)(H,326,398)(H,327,396)(H,328,397)(H,329,399)(H,330,405)(H,331,410)(H,332,417)(H,333,432)(H,334,429)(H,335,430)(H,336,431)(H,337,439)(H,338,416)(H,339,433)(H,340,407)(H,341,419)(H,342,418)(H,343,422)(H,344,424)(H,345,406)(H,346,420)(H,347,423)(H,348,409)(H,349,436)(H,350,435)(H,351,438)(H,352,441)(H,353,408)(H,354,415)(H,355,421)(H,356,425)(H,357,434)(H,358,442)(H,359,426)(H,360,411)(H,361,440)(H,362,427)(H,363,412)(H,364,413)(H,387,388)(H,389,390)(H,391,392)(H,393,394)(H,446,447)(H4,294,295,306)(H4,296,297,307)(H4,298,299,308)(H4,300,301,309)(H4,302,303,310)(H4,304,305,311)
InChi Key ZPNFWUPYTFPOJU-UHFFFAOYSA-N
Canonical SMILES CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(=O)NC(C(=O)NCC(=O)N6CCCC6C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)CC7=CC=CC=C7)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CCC(=O)N)C(C)O)CC8=CC=CC=C8)C(C)C)CC9=CC=C(C=C9)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)C)CCCCN)C(C)O)CC1=CC=C(C=C1)O)CCC(=O)O)CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)NC(C)C(=O)O)C(C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)CC1=CC=C(C=C1)O)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)CCCNC(=N)N)C(C)CC
Isomeric SMILES CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(=O)NC(C(=O)NCC(=O)N6CCCC6C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)CC7=CC=CC=C7)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CCC(=O)N)C(C)O)CC8=CC=CC=C8)C(C)C)CC9=CC=C(C=C9)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)C)CCCCN)C(C)O)CC1=CC=C(C=C1)O)CCC(=O)O)CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)NC(C)C(=O)O)C(C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)CC1=CC=C(C=C1)O)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)CCCNC(=N)N)C(C)CC
PubChem CID 22833874
Molecular Weight 6511.44

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

31 results found

Lot NumberCertificate TypeDateItem
H2422024Certificate of AnalysisAug 08, 2024 A105534
H2422023Certificate of AnalysisAug 08, 2024 A105534
H2422022Certificate of AnalysisAug 08, 2024 A105534
H2422021Certificate of AnalysisAug 08, 2024 A105534
F2215313Certificate of AnalysisMar 08, 2024 A105534
F2215315Certificate of AnalysisMar 08, 2024 A105534
F2215314Certificate of AnalysisMar 08, 2024 A105534
F2215311Certificate of AnalysisMar 08, 2024 A105534
F2215310Certificate of AnalysisMar 08, 2024 A105534
F2215309Certificate of AnalysisMar 08, 2024 A105534
C2401094Certificate of AnalysisFeb 21, 2024 A105534
C2401093Certificate of AnalysisFeb 21, 2024 A105534
B2216372Certificate of AnalysisNov 13, 2023 A105534
B2216370Certificate of AnalysisNov 13, 2023 A105534
B2216362Certificate of AnalysisNov 13, 2023 A105534
B2216338Certificate of AnalysisNov 13, 2023 A105534
K2324100Certificate of AnalysisJul 05, 2023 A105534
I2216083Certificate of AnalysisJul 05, 2023 A105534
I2216082Certificate of AnalysisJul 05, 2023 A105534
I2216080Certificate of AnalysisJul 05, 2023 A105534
I2216078Certificate of AnalysisJul 05, 2023 A105534
I2216076Certificate of AnalysisJul 05, 2023 A105534
I2216084Certificate of AnalysisJul 05, 2023 A105534
I2216073Certificate of AnalysisJul 05, 2023 A105534
G2131044Certificate of AnalysisMay 09, 2023 A105534
G2131043Certificate of AnalysisMay 09, 2023 A105534
G2131042Certificate of AnalysisMay 09, 2023 A105534
G2131041Certificate of AnalysisMay 09, 2023 A105534
G2131040Certificate of AnalysisMay 09, 2023 A105534
B2105006Certificate of AnalysisDec 12, 2022 A105534
B2216341Certificate of AnalysisJan 18, 2022 A105534

Show more⌵

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Recombinant Aprotinin - 10mM in Water, used for , CAS No. 9087-70-1, by Aladdin Scientific
    Recombinant Aprotinin

    Starting at $1,190.90

  2. Recombinant Aprotinin - ≥3 EPU/mg, used for , CAS No. 9087-70-1, by
    Recombinant Aprotinin

    Starting at $378.90

  3. Aprotinin - High purity grade, used for , CAS No. 9087-70-1, by
    Aprotinin

    Starting at $233.90

FAQs and Articles

FAQ
Chromatin preparation from tissues for chromatin immunoprecipitation (ChIP)
Categories: Protocols
Tags:
Electrophoresis ChIP Lysis buffer Aprotinin

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Liu Jing, Bai Xinpeng, Fu Pengcheng.  (2022)  In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity.  JOURNAL OF APPLIED PHYCOLOGY,  34  (3): (1497-1511).  [PMID:] [10.1007/s10811-022-02732-z]
2. Erdong Yuan, Shiying Nie, Chunli Qi, Bo Chang, Jiaoyan Ren.  (2021)  Effect of Scomberomorus niphonius peptide on the characteristics of resveratrol.  Food & Function,  12  (22): (11449-11459).  [PMID:34693420] [10.1039/D1FO01333E]
3. Fanglin Shen, Dan Li, Jianmin Chen.  (2022)  Mechanistic toxicity assessment of fine particulate matter emitted from fuel combustion via pathway-based approaches in human cells.  SCIENCE OF THE TOTAL ENVIRONMENT,  806  (150214).  [PMID:34571223] [10.1016/j.scitotenv.2021.150214]
4. Jiantao Ping, Wenli Wu, Lubin Qi, Jie Liu, Jinpeng Liu, Binglu Zhao, Quanbo Wang, Li Yu, Jin-Ming Lin, Qiongzheng Hu.  (2021)  Hydrogel-assisted paper-based lateral flow sensor for the detection of trypsin in human serum.  BIOSENSORS & BIOELECTRONICS,  192  (113548).  [PMID:34385014] [10.1016/j.bios.2021.113548]
5. Jia-Yu Shi, Hai-Yan Pan, Kun Liu, Min Pan, Guo-Jun Si.  (2020)  Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,  690  (108460).  [PMID:32603715] [10.1016/j.abb.2020.108460]
6. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou.  (2019)  Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.  Experimental and Therapeutic Medicine,  17  (5): (3501-3508).  [PMID:30988730] [10.3892/etm.2019.7352]
7. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan.  (2017)  Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens.  JOURNAL OF ASIA-PACIFIC ENTOMOLOGY,  20  (1340).  [PMID:] [10.1016/j.aspen.2017.10.005]

References

1. Author': None.  (2022)  Late-Breaking Abstracts for ECO2022..  Obes Facts,  15 Suppl 1  (241-286).  [PMID:35500565]
2. Wegscheid ML et al..  (2021)  Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis..  Cell Rep,  36  (109315).  [PMID:34233200]
3. Liu Jing, Bai Xinpeng, Fu Pengcheng.  (2022)  In silico and in vitro assessment of bioactive peptides from Arthrospira platensis phycobiliproteins for DPP-IV inhibitory activity, ACE inhibitory activity, and antioxidant activity.  JOURNAL OF APPLIED PHYCOLOGY,  34  (3): (1497-1511).  [PMID:] [10.1007/s10811-022-02732-z]
4. Erdong Yuan, Shiying Nie, Chunli Qi, Bo Chang, Jiaoyan Ren.  (2021)  Effect of Scomberomorus niphonius peptide on the characteristics of resveratrol.  Food & Function,  12  (22): (11449-11459).  [PMID:34693420] [10.1039/D1FO01333E]
5. Fanglin Shen, Dan Li, Jianmin Chen.  (2022)  Mechanistic toxicity assessment of fine particulate matter emitted from fuel combustion via pathway-based approaches in human cells.  SCIENCE OF THE TOTAL ENVIRONMENT,  806  (150214).  [PMID:34571223] [10.1016/j.scitotenv.2021.150214]
6. Jiantao Ping, Wenli Wu, Lubin Qi, Jie Liu, Jinpeng Liu, Binglu Zhao, Quanbo Wang, Li Yu, Jin-Ming Lin, Qiongzheng Hu.  (2021)  Hydrogel-assisted paper-based lateral flow sensor for the detection of trypsin in human serum.  BIOSENSORS & BIOELECTRONICS,  192  (113548).  [PMID:34385014] [10.1016/j.bios.2021.113548]
7. Jia-Yu Shi, Hai-Yan Pan, Kun Liu, Min Pan, Guo-Jun Si.  (2020)  Expression of ectopic trypsin in atherosclerotic plaques and the effects of aprotinin on plaque stability.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,  690  (108460).  [PMID:32603715] [10.1016/j.abb.2020.108460]
8. Jing Jin, Qiao‑Yun Hu, Wen‑Wen Xu, Wen‑Jia Zhu, Bei Liu, Jing Liu, Wei Wang, Hui‑Fang Zhou.  (2019)  Tanshinone IIA attenuates estradiol‑induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary.  Experimental and Therapeutic Medicine,  17  (5): (3501-3508).  [PMID:30988730] [10.3892/etm.2019.7352]
9. Yunhua Zhang, Jinyun Ji, Xiao Zhao, Ruoheng Jin, Jianhong Li, Hu Wan.  (2017)  Expression, purification and enzymatic properties of a β-N-acetylhexosaminidase from brown planthopper, Nilaparvata lugens.  JOURNAL OF ASIA-PACIFIC ENTOMOLOGY,  20  (1340).  [PMID:] [10.1016/j.aspen.2017.10.005]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.