Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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A126073-1g | 1g | In stock | $44.90 | |
A126073-5g | 5g | In stock | $119.90 | |
A126073-25g | 25g | In stock | $394.90 | |
A126073-100g | 100g | In stock | $1,419.90 | |
A126073-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $6,386.90 |
Inhibits viral DNA polymerase. Antiherpetic agent.
Synonyms | Cargosil | CAS-59277-89-3 | VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY B (EP IMPURITY) | VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY B [EP IMPURITY] | Maynar | acyclovir | NSC-758477 | ACYCLOVIR [USP-RS] | 1 -(t-Butyloxycarbonyl)-piperidine-2(S)-carboxyl |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines, |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Human herpesvirus 1 DNA polymerase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Aciclovir is a synthetic nucleoside analogue active against herpesviruses. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488202820 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202820 |
IUPAC Name | 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one |
INCHI | InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) |
InChi Key | MKUXAQIIEYXACX-UHFFFAOYSA-N |
Canonical SMILES | C1=NC2=C(N1COCCO)N=C(NC2=O)N |
Isomeric SMILES | C1=NC2=C(N1COCCO)N=C(NC2=O)N |
WGK Germany | 2 |
RTECS | UP0791400 |
PubChem CID | 135398513 |
Molecular Weight | 225.2 |
Reaxy-Rn | 1219402 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
C23031328 | Certificate of Analysis | Dec 06, 2024 | A126073 |
C23031231 | Certificate of Analysis | Dec 06, 2024 | A126073 |
C23031230 | Certificate of Analysis | Dec 06, 2024 | A126073 |
C23031229 | Certificate of Analysis | Dec 06, 2024 | A126073 |
G2415307 | Certificate of Analysis | Jul 23, 2024 | A126073 |
I2403065 | Certificate of Analysis | Jul 23, 2024 | A126073 |
G2415329 | Certificate of Analysis | Jul 23, 2024 | A126073 |
G2415330 | Certificate of Analysis | Jul 23, 2024 | A126073 |
H2217107 | Certificate of Analysis | May 31, 2024 | A126073 |
H2217110 | Certificate of Analysis | May 31, 2024 | A126073 |
H2217148 | Certificate of Analysis | May 31, 2024 | A126073 |
G2123174 | Certificate of Analysis | May 10, 2023 | A126073 |
C1516024 | Certificate of Analysis | Sep 20, 2022 | A126073 |
D2310211 | Certificate of Analysis | Jun 23, 2022 | A126073 |
D2310189 | Certificate of Analysis | Jun 23, 2022 | A126073 |
H2217108 | Certificate of Analysis | Jun 23, 2022 | A126073 |
H2217109 | Certificate of Analysis | Jun 23, 2022 | A126073 |
A2412033 | Certificate of Analysis | Jun 23, 2022 | A126073 |
Solubility | Soluble in water (partly), DMSO (50 mg/ml), DMF (1 mg/ml), 1eq. HCl (50 mM), and dilute alkalies. |
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Melt Point(°C) | 262°C |
WGK Germany | 2 |
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RTECS | UP0791400 |
Reaxy-Rn | 1219402 |
Merck Index | 146 |
1. Yu Cai, Liying Xin, Hui Li, Peng Sun, Chao Liu, Liang Fang. (2024) Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions. JOURNAL OF CONTROLLED RELEASE, 365 (24): (161). [PMID:37972766] [10.1016/j.jconrel.2023.11.016] |
2. Xinyu Song, Yang Shi, Zelin Wu, Bingkun Huang, Xinhao Wang, Heng Zhang, Peng Zhou, Wen Liu, Zhicheng Pan, Zhaokun Xiong, Bo Lai. (2024) Unraveling the discriminative mechanisms for peroxy activation via atomically dispersed Fe-N5 sites for tunable water decontamination. APPLIED CATALYSIS B-ENVIRONMENTAL, 340 (123240). [PMID:] [10.1016/j.apcatb.2023.123240] |
3. Ting Zhang, Ge Bai, Nan Cai, Yongqian Lei, Pengran Guo, Jingwei Xu. (2023) The carbon-doped Fe3O4 montmorillonite particle electrode for the degradation of antiviral drugs in electro-Fenton system. APPLIED CLAY SCIENCE, 243 (107056). [PMID:] [10.1016/j.clay.2023.107056] |
4. Fan-Zhi Bu, Yue-Ming Yu, Min Zhang, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li. (2023) Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and Synergy: A Theoretical and Experimental Integration Research. CRYSTAL GROWTH & DESIGN, 23 (8): (5868–5882). [PMID:] [10.1021/acs.cgd.3c00489] |
5. Shuang Shan, Jie Hu, Zhiyun Zheng, Shuangying Gui, Yanqiu Long, Danqing Wu, Ning He. (2023) Development and Assessment of Acyclovir Gel Plaster Containing Sponge Spicules. JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:37331627] [10.1016/j.xphs.2023.06.008] |
6. Liu Yang, Hao Wu, Congcong Luo, Yang Zhao, Rongbo Dai, Zhiqing Li, Xu Zhang, Ze Gong, Zeyu Cai, Yicong Shen, Fang Yu, Wei Li, Hongmei Zhao, Tao Zhang, Junming Zhu, Yi Fu, Jing Wang, Wei Kong. (2023) Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 43 (e172–e189). [PMID:37128913] [10.1161/ATVBAHA.122.318788] |
7. Yahan Yu, Chunxiu Yu, Zelin Wu, Bingkun Huang, Peng Zhou, Heng Zhang, Wen Liu, Yucheng Liu, Zhaokun Xiong, Bo Lai. (2023) Switching the primary mechanism from a radical to a nonradical pathway in electrocatalytic ozonation by onsite alternating anode and cathode. CHEMICAL ENGINEERING JOURNAL, 457 (141340). [PMID:] [10.1016/j.cej.2023.141340] |
8. Yanping Wei, Liangyuan Yao, Yiyong Wu, Xia Liu, Jinxia Feng, Jianhua Ding, Kanghua Li, Quanguo He. (2022) Ultrasensitive electrochemical detection for nanomolarity Acyclovir at ferrous molybdate nanorods and graphene oxide composited glassy carbon electrode. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 641 (128601). [PMID:] [10.1016/j.colsurfa.2022.128601] |
9. Zhihua Song, Yanqin Song, Yinghao Wang, Jinqiu Liu, Yumeng Wang, Wen Lin, Yaqi Wang, Jinhua Li, Jiping Ma, Gangqiang Yang, Lingxin Chen. (2022) Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases. TALANTA, 239 (123115). [PMID:34890940] [10.1016/j.talanta.2021.123115] |
10. Muning Chen, Jian Lu, Jia Gao, Chao Yu, Wendong Xing, Jiangdong Dai, Minjia Meng, Yongsheng Yan, Yilin Wu. (2022) Design of self-cleaning molecularly imprinted membrane with antibacterial ability for high-selectively separation of ribavirin. JOURNAL OF MEMBRANE SCIENCE, 642 (119994). [PMID:] [10.1016/j.memsci.2021.119994] |
11. Xiaoyu Xu, Zishan Zeng, Xin Ding, Ting Shan, Qiuxing Liu, Meixu Chen, Jie Chen, Meng Xia, Yuanfeng He, Zeqian Huang, Yanjuan Huang, Chunshun Zhao. (2021) Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy. BIOMATERIALS, 277 (121128). [PMID:34537502] [10.1016/j.biomaterials.2021.121128] |
12. Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu. (2021) A molecular mechanism investigation of the transdermal/topical absorption classification system on the basis of drug skin permeation and skin retention. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 608 (121082). [PMID:34506925] [10.1016/j.ijpharm.2021.121082] |
13. Binge Deng, Xia Luo, Meng Zhang, Liming Ye, Yu Chen. (2019) Quantitative detection of acyclovir by surface enhanced Raman spectroscopy using a portable Raman spectrometer coupled with multivariate data analysis. COLLOIDS AND SURFACES B-BIOINTERFACES, 173 (286). [PMID:30308453] [10.1016/j.colsurfb.2018.09.058] |
14. Chunyang Nie, Zhimin Ao, Xiaoguang Duan, Chengying Wang, Shaobin Wang, Taicheng An. (2018) Degradation of aniline by electrochemical activation of peroxydisulfate at MWCNT cathode: The proofed concept of nonradical oxidation process. CHEMOSPHERE, 206 (432). [PMID:29758500] [10.1016/j.chemosphere.2018.04.173] |
15. Yu-Feng Shen, Lei Liu, Wei-Chao Chen, Yang Hu, Bin Zhu, Gao-Xue Wang. (2018) Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus. AQUACULTURE, 483 (252). [PMID:32287458] [10.1016/j.aquaculture.2017.09.001] |
16. Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang. (2017) Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1). Pharmacological Reports, 69 (1254). [PMID:29128807] [10.1016/j.pharep.2017.06.012] |
17. Tianwei Lv, Hongyuan Yan, Jiankun Cao, Shiru Liang. (2015) Hydrophilic Molecularly Imprinted Resorcinol–Formaldehyde–Melamine Resin Prepared in Water with Excellent Molecular Recognition in Aqueous Matrices. ANALYTICAL CHEMISTRY, 87 (21): (11084–11091). [PMID:26441379] [10.1021/acs.analchem.5b03253] |
1. Datta AK, Colby BM, Shaw JE, Pagano JS. (1980) Acyclovir inhibition of Epstein-Barr virus replication.. Proc Natl Acad Sci USA, 77 (9): (5163-6). [PMID:6254061] [10.1021/op500134e] |
2. Allaudeen HS, Descamps J, Sehgal RK. (1982) Mode of action of acyclovir triphosphate on herpesviral and cellular DNA polymerases.. Antiviral Res, 2 (3): (123-33). [PMID:6291456] [10.1021/op500134e] |
3. Gnann Jr JW, Barton NH, Whitley RJ. (1983) Acyclovir: mechanism of action, pharmacokinetics, safety and clinical applications.. Pharmacotherapy, 3 (5): (275-83). [PMID:6359082] [10.1021/op500134e] |
4. Yu Cai, Liying Xin, Hui Li, Peng Sun, Chao Liu, Liang Fang. (2024) Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions. JOURNAL OF CONTROLLED RELEASE, 365 (24): (161). [PMID:37972766] [10.1016/j.jconrel.2023.11.016] |
5. Xinyu Song, Yang Shi, Zelin Wu, Bingkun Huang, Xinhao Wang, Heng Zhang, Peng Zhou, Wen Liu, Zhicheng Pan, Zhaokun Xiong, Bo Lai. (2024) Unraveling the discriminative mechanisms for peroxy activation via atomically dispersed Fe-N5 sites for tunable water decontamination. APPLIED CATALYSIS B-ENVIRONMENTAL, 340 (123240). [PMID:] [10.1016/j.apcatb.2023.123240] |
6. Ting Zhang, Ge Bai, Nan Cai, Yongqian Lei, Pengran Guo, Jingwei Xu. (2023) The carbon-doped Fe3O4 montmorillonite particle electrode for the degradation of antiviral drugs in electro-Fenton system. APPLIED CLAY SCIENCE, 243 (107056). [PMID:] [10.1016/j.clay.2023.107056] |
7. Fan-Zhi Bu, Yue-Ming Yu, Min Zhang, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li. (2023) Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and Synergy: A Theoretical and Experimental Integration Research. CRYSTAL GROWTH & DESIGN, 23 (8): (5868–5882). [PMID:] [10.1021/acs.cgd.3c00489] |
8. Shuang Shan, Jie Hu, Zhiyun Zheng, Shuangying Gui, Yanqiu Long, Danqing Wu, Ning He. (2023) Development and Assessment of Acyclovir Gel Plaster Containing Sponge Spicules. JOURNAL OF PHARMACEUTICAL SCIENCES, [PMID:37331627] [10.1016/j.xphs.2023.06.008] |
9. Liu Yang, Hao Wu, Congcong Luo, Yang Zhao, Rongbo Dai, Zhiqing Li, Xu Zhang, Ze Gong, Zeyu Cai, Yicong Shen, Fang Yu, Wei Li, Hongmei Zhao, Tao Zhang, Junming Zhu, Yi Fu, Jing Wang, Wei Kong. (2023) Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 43 (e172–e189). [PMID:37128913] [10.1161/ATVBAHA.122.318788] |
10. Yahan Yu, Chunxiu Yu, Zelin Wu, Bingkun Huang, Peng Zhou, Heng Zhang, Wen Liu, Yucheng Liu, Zhaokun Xiong, Bo Lai. (2023) Switching the primary mechanism from a radical to a nonradical pathway in electrocatalytic ozonation by onsite alternating anode and cathode. CHEMICAL ENGINEERING JOURNAL, 457 (141340). [PMID:] [10.1016/j.cej.2023.141340] |
11. Yanping Wei, Liangyuan Yao, Yiyong Wu, Xia Liu, Jinxia Feng, Jianhua Ding, Kanghua Li, Quanguo He. (2022) Ultrasensitive electrochemical detection for nanomolarity Acyclovir at ferrous molybdate nanorods and graphene oxide composited glassy carbon electrode. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 641 (128601). [PMID:] [10.1016/j.colsurfa.2022.128601] |
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