Aciclovir - ≥99%, high purity , Human herpesvirus 1 DNA polymerase inhibitor, CAS No.59277-89-3, Human herpesvirus 1 DNA polymerase inhibitor

Item Number
A126073
Grouped product items
SKUSizeAvailabilityPrice Qty
A126073-1g
1g
In stock
$44.90
A126073-5g
5g
In stock
$119.90
A126073-25g
25g
In stock
$394.90
A126073-100g
100g
In stock
$1,419.90
A126073-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$6,386.90

Inhibits viral DNA polymerase. Antiherpetic agent.

Basic Description

SynonymsCargosil | CAS-59277-89-3 | VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY B (EP IMPURITY) | VALACICLOVIR HYDROCHLORIDE HYDRATE IMPURITY B [EP IMPURITY] | Maynar | acyclovir | NSC-758477 | ACYCLOVIR [USP-RS] | 1 -(t-Butyloxycarbonyl)-piperidine-2(S)-carboxyl
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsAcyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines,
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionHuman herpesvirus 1 DNA polymerase inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Aciclovir is a synthetic nucleoside analogue active against herpesviruses.
An antiviral compound that can be used to induce apoptosis.

Associated Targets(Human)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLA1 Tclin DNA polymerase alpha subunit (225 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Human herpesvirus 1 DNA polymerase (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TK Thymidine kinase (276 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pnp Purine nucleoside phosphorylase (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Equus caballus (156 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 2 (4932 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Equid alphaherpesvirus 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human gammaherpesvirus 4 (1538 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human respirovirus 3 (1674 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human orthopneumovirus (392 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Influenza B virus (2113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 3 (4092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Suid alphaherpesvirus 1 (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cytomegalovirus (1023 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human betaherpesvirus 5 (5122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vaccinia virus (4609 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 1 (11089 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bovine alphaherpesvirus 1 (7 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis B virus (7925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Echovirus E9 (43 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Coxsackievirus B3 (1096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Coxsackievirus B5 (476 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Poliovirus 1 (1274 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
African swine fever virus (22 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human adenovirus 2 (239 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488202820
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488202820
IUPAC Name 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one
INCHI InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
InChi Key MKUXAQIIEYXACX-UHFFFAOYSA-N
Canonical SMILES C1=NC2=C(N1COCCO)N=C(NC2=O)N
Isomeric SMILES C1=NC2=C(N1COCCO)N=C(NC2=O)N
WGK Germany 2
RTECS UP0791400
PubChem CID 135398513
Molecular Weight 225.2
Reaxy-Rn 1219402

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

18 results found

Lot NumberCertificate TypeDateItem
C23031328Certificate of AnalysisDec 06, 2024 A126073
C23031231Certificate of AnalysisDec 06, 2024 A126073
C23031230Certificate of AnalysisDec 06, 2024 A126073
C23031229Certificate of AnalysisDec 06, 2024 A126073
G2415307Certificate of AnalysisJul 23, 2024 A126073
I2403065Certificate of AnalysisJul 23, 2024 A126073
G2415329Certificate of AnalysisJul 23, 2024 A126073
G2415330Certificate of AnalysisJul 23, 2024 A126073
H2217107Certificate of AnalysisMay 31, 2024 A126073
H2217110Certificate of AnalysisMay 31, 2024 A126073
H2217148Certificate of AnalysisMay 31, 2024 A126073
G2123174Certificate of AnalysisMay 10, 2023 A126073
C1516024Certificate of AnalysisSep 20, 2022 A126073
D2310211Certificate of AnalysisJun 23, 2022 A126073
D2310189Certificate of AnalysisJun 23, 2022 A126073
H2217108Certificate of AnalysisJun 23, 2022 A126073
H2217109Certificate of AnalysisJun 23, 2022 A126073
A2412033Certificate of AnalysisJun 23, 2022 A126073

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Chemical and Physical Properties

SolubilitySoluble in water (partly), DMSO (50 mg/ml), DMF (1 mg/ml), 1eq. HCl (50 mM), and dilute alkalies.
Melt Point(°C)262°C

Safety and Hazards(GHS)

WGK Germany 2
RTECS UP0791400
Reaxy-Rn 1219402
Merck Index 146

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Citations of This Product

1. Yu Cai, Liying Xin, Hui Li, Peng Sun, Chao Liu, Liang Fang.  (2024)  Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions.  JOURNAL OF CONTROLLED RELEASE,  365  (24): (161).  [PMID:37972766] [10.1016/j.jconrel.2023.11.016]
2. Xinyu Song, Yang Shi, Zelin Wu, Bingkun Huang, Xinhao Wang, Heng Zhang, Peng Zhou, Wen Liu, Zhicheng Pan, Zhaokun Xiong, Bo Lai.  (2024)  Unraveling the discriminative mechanisms for peroxy activation via atomically dispersed Fe-N5 sites for tunable water decontamination.  APPLIED CATALYSIS B-ENVIRONMENTAL,  340  (123240).  [PMID:] [10.1016/j.apcatb.2023.123240]
3. Ting Zhang, Ge Bai, Nan Cai, Yongqian Lei, Pengran Guo, Jingwei Xu.  (2023)  The carbon-doped Fe3O4 montmorillonite particle electrode for the degradation of antiviral drugs in electro-Fenton system.  APPLIED CLAY SCIENCE,  243  (107056).  [PMID:] [10.1016/j.clay.2023.107056]
4. Fan-Zhi Bu, Yue-Ming Yu, Min Zhang, Cui-Wei Yan, Zhi-Yong Wu, Yan-Tuan Li.  (2023)  Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and Synergy: A Theoretical and Experimental Integration Research.  CRYSTAL GROWTH & DESIGN,  23  (8): (5868–5882).  [PMID:] [10.1021/acs.cgd.3c00489]
5. Shuang Shan, Jie Hu, Zhiyun Zheng, Shuangying Gui, Yanqiu Long, Danqing Wu, Ning He.  (2023)  Development and Assessment of Acyclovir Gel Plaster Containing Sponge Spicules.  JOURNAL OF PHARMACEUTICAL SCIENCES,      [PMID:37331627] [10.1016/j.xphs.2023.06.008]
6. Liu Yang, Hao Wu, Congcong Luo, Yang Zhao, Rongbo Dai, Zhiqing Li, Xu Zhang, Ze Gong, Zeyu Cai, Yicong Shen, Fang Yu, Wei Li, Hongmei Zhao, Tao Zhang, Junming Zhu, Yi Fu, Jing Wang, Wei Kong.  (2023)  Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice.  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,  43  (e172–e189).  [PMID:37128913] [10.1161/ATVBAHA.122.318788]
7. Yahan Yu, Chunxiu Yu, Zelin Wu, Bingkun Huang, Peng Zhou, Heng Zhang, Wen Liu, Yucheng Liu, Zhaokun Xiong, Bo Lai.  (2023)  Switching the primary mechanism from a radical to a nonradical pathway in electrocatalytic ozonation by onsite alternating anode and cathode.  CHEMICAL ENGINEERING JOURNAL,  457  (141340).  [PMID:] [10.1016/j.cej.2023.141340]
8. Yanping Wei, Liangyuan Yao, Yiyong Wu, Xia Liu, Jinxia Feng, Jianhua Ding, Kanghua Li, Quanguo He.  (2022)  Ultrasensitive electrochemical detection for nanomolarity Acyclovir at ferrous molybdate nanorods and graphene oxide composited glassy carbon electrode.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  641  (128601).  [PMID:] [10.1016/j.colsurfa.2022.128601]
9. Zhihua Song, Yanqin Song, Yinghao Wang, Jinqiu Liu, Yumeng Wang, Wen Lin, Yaqi Wang, Jinhua Li, Jiping Ma, Gangqiang Yang, Lingxin Chen.  (2022)  Chromatographic performance of zidovudine imprinted polymers coated silica stationary phases.  TALANTA,  239  (123115).  [PMID:34890940] [10.1016/j.talanta.2021.123115]
10. Muning Chen, Jian Lu, Jia Gao, Chao Yu, Wendong Xing, Jiangdong Dai, Minjia Meng, Yongsheng Yan, Yilin Wu.  (2022)  Design of self-cleaning molecularly imprinted membrane with antibacterial ability for high-selectively separation of ribavirin.  JOURNAL OF MEMBRANE SCIENCE,  642  (119994).  [PMID:] [10.1016/j.memsci.2021.119994]
11. Xiaoyu Xu, Zishan Zeng, Xin Ding, Ting Shan, Qiuxing Liu, Meixu Chen, Jie Chen, Meng Xia, Yuanfeng He, Zeqian Huang, Yanjuan Huang, Chunshun Zhao.  (2021)  Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy.  BIOMATERIALS,  277  (121128).  [PMID:34537502] [10.1016/j.biomaterials.2021.121128]
12. Qi Tian, Peng Quan, Liang Fang, Hui Xu, Chao Liu.  (2021)  A molecular mechanism investigation of the transdermal/topical absorption classification system on the basis of drug skin permeation and skin retention.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  608  (121082).  [PMID:34506925] [10.1016/j.ijpharm.2021.121082]
13. Binge Deng, Xia Luo, Meng Zhang, Liming Ye, Yu Chen.  (2019)  Quantitative detection of acyclovir by surface enhanced Raman spectroscopy using a portable Raman spectrometer coupled with multivariate data analysis.  COLLOIDS AND SURFACES B-BIOINTERFACES,  173  (286).  [PMID:30308453] [10.1016/j.colsurfb.2018.09.058]
14. Chunyang Nie, Zhimin Ao, Xiaoguang Duan, Chengying Wang, Shaobin Wang, Taicheng An.  (2018)  Degradation of aniline by electrochemical activation of peroxydisulfate at MWCNT cathode: The proofed concept of nonradical oxidation process.  CHEMOSPHERE,  206  (432).  [PMID:29758500] [10.1016/j.chemosphere.2018.04.173]
15. Yu-Feng Shen, Lei Liu, Wei-Chao Chen, Yang Hu, Bin Zhu, Gao-Xue Wang.  (2018)  Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus.  AQUACULTURE,  483  (252).  [PMID:32287458] [10.1016/j.aquaculture.2017.09.001]
16. Ting Wu, Haixin Li, Jiasheng Chen, Ying Cao, Weimin Fu, Pingzheng Zhou, Jianxin Pang.  (2017)  Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1).  Pharmacological Reports,  69  (1254).  [PMID:29128807] [10.1016/j.pharep.2017.06.012]
17. Tianwei Lv, Hongyuan Yan, Jiankun Cao, Shiru Liang.  (2015)  Hydrophilic Molecularly Imprinted Resorcinol–Formaldehyde–Melamine Resin Prepared in Water with Excellent Molecular Recognition in Aqueous Matrices.  ANALYTICAL CHEMISTRY,  87  (21): (11084–11091).  [PMID:26441379] [10.1021/acs.analchem.5b03253]

References

1. Datta AK, Colby BM, Shaw JE, Pagano JS.  (1980)  Acyclovir inhibition of Epstein-Barr virus replication..  Proc Natl Acad Sci USA,  77  (9): (5163-6).  [PMID:6254061] [10.1021/op500134e]
2. Allaudeen HS, Descamps J, Sehgal RK.  (1982)  Mode of action of acyclovir triphosphate on herpesviral and cellular DNA polymerases..  Antiviral Res,  (3): (123-33).  [PMID:6291456] [10.1021/op500134e]
3. Gnann Jr JW, Barton NH, Whitley RJ.  (1983)  Acyclovir: mechanism of action, pharmacokinetics, safety and clinical applications..  Pharmacotherapy,  (5): (275-83).  [PMID:6359082] [10.1021/op500134e]
4. Yu Cai, Liying Xin, Hui Li, Peng Sun, Chao Liu, Liang Fang.  (2024)  Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions.  JOURNAL OF CONTROLLED RELEASE,  365  (24): (161).  [PMID:37972766] [10.1016/j.jconrel.2023.11.016]
5. Xinyu Song, Yang Shi, Zelin Wu, Bingkun Huang, Xinhao Wang, Heng Zhang, Peng Zhou, Wen Liu, Zhicheng Pan, Zhaokun Xiong, Bo Lai.  (2024)  Unraveling the discriminative mechanisms for peroxy activation via atomically dispersed Fe-N5 sites for tunable water decontamination.  APPLIED CATALYSIS B-ENVIRONMENTAL,  340  (123240).  [PMID:] [10.1016/j.apcatb.2023.123240]
6. Ting Zhang, Ge Bai, Nan Cai, Yongqian Lei, Pengran Guo, Jingwei Xu.  (2023)  The carbon-doped Fe3O4 montmorillonite particle electrode for the degradation of antiviral drugs in electro-Fenton system.  APPLIED CLAY SCIENCE,  243  (107056).  [PMID:] [10.1016/j.clay.2023.107056]
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Solution Calculators