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A12B4C3 - ≥98%(HPLC), high purity , CAS No.1005129-80-5
Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor
Basic Description Synonyms A12B4C3 | 1005129-80-5 | BCB02_000099 | A 12B4C3;A-12B4C3 | 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione | SCHEMBL1703545 | CHEMBL4303462 | DTXSID90425001 | A 12B4C3 | A12 B4 C3 | A12-B4-C3 | AKOS025142047 | AKOS Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50= 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells. Storage Temp Store at 2-8°C Shipped In Wet ice
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-(1-hydroxyundecyl)-1-(4-nitroanilino)-6-phenyl-4a,7a-dihydro-2H-pyrrolo[3,4-b]pyridine-5,7-dione INCHI InChI=1S/C30H38N4O5/c1-2-3-4-5-6-7-8-12-15-27(35)26-21-20-25-28(30(37)32(29(25)36)23-13-10-9-11-14-23)33(26)31-22-16-18-24(19-17-22)34(38)39/h9-11,13-14,16-21,25-28,31,35H,2-8,12,15H2,1H3 InChi Key KVHGJAKTBPFFNV-UHFFFAOYSA-N Canonical SMILES CCCCCCCCCCC(C1C=CC2C(N1NC3=CC=C(C=C3)[N+](=O)[O-])C(=O)N(C2=O)C4=CC=CC=C4)O Isomeric SMILES CCCCCCCCCCC(C1C=CC2C(N1NC3=CC=C(C=C3)[N+](=O)[O-])C(=O)N(C2=O)C4=CC=CC=C4)O PubChem CID 6610064 Molecular Weight 534.65
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 53.47, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H301: Toxic if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
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