7-Aminoactinomycin D - ≥97.0% (HPLC), high purity , CAS No.7240-37-1

Item Number

A131295

• Synonyms: 7-Aminoactinomycin D|Actinomycin D, 7-amino-|7240-37-1|FLU 402|7-amino-AMD|7-Amino Actinomycin D|7-AAD|CHEBI:52304|DXS32PH95R|CHEMBL2159004|2,7-diamino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan
• Specifications & Purity: ≥97.0% (HPLC)
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Dry ice

Product Description

7-Aminoactinomycin D ，an analog of the antibiotic actinomycin D ，is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies. As a fluorescent DNA dye, 7-AAD is able to intercalate DNA via binding to the GC regions. When used in flow cytometery, 7-AAD can be used to discriminate between live cells as well as early and late apoptosis. Additionally, 7-AAD can also be combined with other staining procedures for analysis of intracellular and cell surface antigens enabling multiparametric analysis. When utilizing 7-AAD with flow cytometery, early and late apoptosis can be studied by varying the concentration of 7-AAD. During apoptosis, the cellular plasma membrane is altered progressively, which allows the cell membrane to become permeable to 7-AAD. 7-AAD staining can also be adapted to include staining with other dyes for intracellular and cell surface antigens. 7-Aminoactinomycin D is an inhibitor of DNA Polymerase and RNA Polymerase
A fluorescent DNA dye for apoptosis and flow cytomtery studies.