A192621 - 98%, high purity , CAS No.195529-54-5, Antagonist of ET B receptor

Item Number

A607282

• Synonyms: A-192621 | 195529-54-5 | A192621 | A 192621 | CHEMBL332794 | 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-((2,6-diethylphenyl)amino)-2-oxoethyl)-2-(4-propoxyphenyl)-, (2R,3R,4S)- | A-192621-1 | A-192621.1 | 5XE882529E | (2R,3R,4S)-4-(benzo[d][1,3]dioxol-5-yl
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: A192621 is a selective; orally available ETB endothelin receptor antagonist. A192621 has been shown to cause an increase in arterial blood pressure and to promote apoptosis in human pulmonary arterial smooth muscle cells.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of ET B receptor

Product Description

A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ETA (IC50 of 4280 nM and Ki of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level.