AA 147 - ≥98%(HPLC), high purity , CAS No.393121-74-9

  • ≥98%(HPLC)
Item Number
A288526
Grouped product items
SKUSizeAvailabilityPrice Qty
A288526-5mg
5mg
In stock
$68.90
A288526-10mg
10mg
In stock
$117.90
A288526-25mg
25mg
In stock
$246.90
A288526-50mg
50mg
In stock
$395.90
A288526-100mg
100mg
In stock
$593.90

ER proteostasis regulator

Basic Description

Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsEndoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogen
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Product description

AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
INCHI InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19)
InChi Key AWHLTHOHBAGPMY-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=C(C=C1)O)NC(=O)CCC2=CC=CC=C2
Isomeric SMILES CC1=CC(=C(C=C1)O)NC(=O)CCC2=CC=CC=C2
PubChem CID 882909
Molecular Weight 255.31

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
K2219019Certificate of AnalysisSep 03, 2022 A288526
K2219020Certificate of AnalysisSep 03, 2022 A288526
K2219021Certificate of AnalysisSep 03, 2022 A288526
K2219022Certificate of AnalysisSep 03, 2022 A288526
K2219023Certificate of AnalysisSep 03, 2022 A288526

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 25.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 25.53, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

Related Documents

Solution Calculators