Basic Description

Synonyms	N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogen
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product description AA147 is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity.

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Atf6 Cyclic AMP-dependent transcription factor ATF-6 alpha (16 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide
INCHI	InChI=1S/C16H17NO2/c1-12-7-9-15(18)14(11-12)17-16(19)10-8-13-5-3-2-4-6-13/h2-7,9,11,18H,8,10H2,1H3,(H,17,19)
InChi Key	AWHLTHOHBAGPMY-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)O)NC(=O)CCC2=CC=CC=C2
Isomeric SMILES	CC1=CC(=C(C=C1)O)NC(=O)CCC2=CC=CC=C2
PubChem CID	882909
Molecular Weight	255.31

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5 results found

Lot Number	Certificate Type	Date	Item
K2219019	Certificate of Analysis	Sep 03, 2022	A288526
K2219020	Certificate of Analysis	Sep 03, 2022	A288526
K2219021	Certificate of Analysis	Sep 03, 2022	A288526
K2219022	Certificate of Analysis	Sep 03, 2022	A288526
K2219023	Certificate of Analysis	Sep 03, 2022	A288526

Solubility	Solvent:DMSO, Max Conc. mg/mL: 25.53, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 25.53, Max Conc. mM: 100

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

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SKU	Size	Availability	Price
A288526-5mg	5mg	In stock	$68.90
A288526-10mg	10mg	In stock	$117.90
A288526-25mg	25mg	In stock	$246.90
A288526-50mg	50mg	In stock	$395.90
A288526-100mg	100mg	In stock	$593.90