Potent and selective ERβagonist (EC50values are 6 and 5000 nM for ERβand ERαrespectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβlevels in combination with ACP-105 in a rat model of Alzhe
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Estrogen receptor-α;Agonist of Estrogen receptor-β
Product Description
product description：
AC-186 is a non-steroidal estrogen receptor β (ERβ) agonist (EC50 = 6 nM in a functional assay).1 It is selective for ERβ over ERα (EC50 = 5,000 nM). AC-186 (10 mg/kg) reduces dopaminergic neuronal loss in the substantia nigra, improves novel object recognition, and improves motor performance in male, but not female, rats in a model of Parkinson’s disease induced by 6-OHDA (Item No. 25330). It reduces tactile allodynia in male, but not female or female ovariectomized, rats in a model of spinal nerve ligation-induced neuropathic pain.2 AC-186 (10 and 30 mg/kg) also reduces tactile allodynia in male rats in a model of neuropathic pain induced by paclitaxel.
1.McFarland K, Price DL, Davis CN, Ma JN, Bonhaus DW, Burstein ES, Olsson R. (2013) AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model.. ACS Chem Neurosci, 4 (9):(1249-55). [PMID:23898966][10.1021/op500134e]
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