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AC 1903 - 10mM in DMSO, high purity , CAS No.831234-13-0
Basic Description Synonyms 831234-13-0 | AC1903 | 1-benzyl-N-[(furan-2-yl)methyl]-1H-1,3-benzodiazol-2-amine | 1-benzyl-N-(furan-2-ylmethyl)-1H-benzimidazol-2-amine | 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine | MLS000084083 | 1-benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine | 1-Benzyl- Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Selective TRPC5 blocker (IC50= 13.6 μM). Also displays weak inhibition at TRPC4 (IC50>100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses sever Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine INCHI InChI=1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21) InChi Key OECUWHDVQIITIS-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2NCC4=CC=CO4 Isomeric SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2NCC4=CC=CO4 PubChem CID 667146 Molecular Weight 303.36
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P405: Store locked up.
P501: Dispose of contents/container to ...
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