AC 1903 - 10mM in DMSO, high purity , CAS No.831234-13-0

Item Number
A426150
Grouped product items
SKUSizeAvailabilityPrice Qty
A426150-1ml
1ml
Available within 8-12 weeks(?)
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$90.90

Selective TRPC5 blocker

Basic Description

Synonyms831234-13-0 | AC1903 | 1-benzyl-N-[(furan-2-yl)methyl]-1H-1,3-benzodiazol-2-amine | 1-benzyl-N-(furan-2-ylmethyl)-1H-benzimidazol-2-amine | 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine | MLS000084083 | 1-benzyl-N-(2-furylmethyl)-1H-benzimidazol-2-amine | 1-Benzyl-
Specifications & PurityMoligand™, 10mM in DMSO
Biochemical and Physiological MechanismsSelective TRPC5 blocker (IC50= 13.6 μM). Also displays weak inhibition at TRPC4 (IC50>100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses sever
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
GradeMoligand™
Product Description

AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.

Associated Targets(Human)

TRPC5 Tchem Short transient receptor potential channel 5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRPC5 Tchem Short transient receptor potential channel 5 (300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NS1 Nonstructural protein 1 (33327 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpc4 Short transient receptor potential channel 4 (1615 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine
INCHI InChI=1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)
InChi Key OECUWHDVQIITIS-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2NCC4=CC=CO4
Isomeric SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3N=C2NCC4=CC=CO4
PubChem CID 667146
Molecular Weight 303.36

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P405:Store locked up.

P501:Dispose of contents/container to ...

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