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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A288562-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $216.90 | |
A288562-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $810.90 |
RARβ2 agonist
Synonyms | AKOS024457947 | SCHEMBL4598579 | LGF3F89BZP | 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid | Q27074132 | BDBM50413272 | Benzoic acid, 4-[4-(2-butoxyethoxy)-5-methyl-2-thiazolyl]-2-fluoro- | 4-(4-(2-butoxyethoxy)-5-methylthiazol-2- |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent RARβ2 agonist (pEC50= 8.1). Selective over RARβ1, RARαand RARγ(pEC50values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649. |
Storage Temp | Room temperature |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Retinoic acid receptor-β |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[4-(2-butoxyethoxy)-5-methyl-1,3-thiazol-2-yl]-2-fluorobenzoic acid |
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INCHI | InChI=1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21) |
InChi Key | HSAOETBFVAWNRP-UHFFFAOYSA-N |
Canonical SMILES | CCCCOCCOC1=C(SC(=N1)C2=CC(=C(C=C2)C(=O)O)F)C |
Isomeric SMILES | CCCCOCCOC1=C(SC(=N1)C2=CC(=C(C=C2)C(=O)O)F)C |
PubChem CID | 11530459 |
Molecular Weight | 353.41 |
PubChem CID | 11530459 |
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ChEMBL Ligand | CHEMBL198997 |
CAS Registry No. | 870773-76-5 |
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Solubility | Solvent:DMSO, Max Conc. mg/mL: 35.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 35.34, Max Conc. mM: 100 |
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