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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A288323-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $106.90 | |
A288323-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $96.90 | |
A288323-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $400.90 | |
A288323-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $346.90 | |
A288323-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,297.90 |
Selective RARβ2 agonist
Synonyms | 59662-49-6 | AC-55649 | 4-(4-octylphenyl)benzoic acid | AC 55649 | AC55649 | 4'-n-octylbiphenyl-4-carboxylic acid | 4'-octyl-[1,1'-Biphenyl]-4-carboxylic acid | 4-N-Octylbiphenyl-4'-carboxylic acid | 4'-octyl-4-biphenylcarboxylic acid | 4'-Octylbiphenyl-4-carboxylic acid | C |
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Specifications & Purity | Moligand™, ≥97% |
Biochemical and Physiological Mechanisms | Potent, isoform-selective RARβ2 receptor agonist (pEC50values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARαrespectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Retinoic acid receptor-β |
Product Description |
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
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IUPAC Name | 4-(4-octylphenyl)benzoic acid |
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INCHI | InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23) |
InChi Key | HXBKPYIEQLLNBK-UHFFFAOYSA-N |
Canonical SMILES | CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O |
Isomeric SMILES | CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O |
PubChem CID | 1714884 |
Molecular Weight | 310.44 |
PubChem CID | 1714884 |
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ChEMBL Ligand | CHEMBL425027 |
CAS Registry No. | 59662-49-6 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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A2426201 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426202 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426203 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426204 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426205 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426211 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426235 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426236 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426238 | Certificate of Analysis | Nov 27, 2023 | A288323 |
A2426239 | Certificate of Analysis | Nov 27, 2023 | A288323 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 31.04, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.76, Max Conc. mM: 25 |
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1. Lund BW, Knapp AE, Piu F, Gauthier NK, Begtrup M, Hacksell U, Olsson R. (2009) Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands.. J Med Chem, 52 (6): (1540-5). [PMID:19239230] |