AC 55649 - 97%, high purity , CAS No.59662-49-6, Agonist of Retinoic acid receptor-β

Item Number
A288323
Grouped product items
SKUSizeAvailabilityPrice Qty
A288323-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$106.90
A288323-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$96.90
A288323-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$400.90
A288323-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$346.90
A288323-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,297.90

Selective RARβ2 agonist

Basic Description

Synonyms59662-49-6 | AC-55649 | 4-(4-octylphenyl)benzoic acid | AC 55649 | AC55649 | 4'-n-octylbiphenyl-4-carboxylic acid | 4'-octyl-[1,1'-Biphenyl]-4-carboxylic acid | 4-N-Octylbiphenyl-4'-carboxylic acid | 4'-octyl-4-biphenylcarboxylic acid | 4'-Octylbiphenyl-4-carboxylic acid | C
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPotent, isoform-selective RARβ2 receptor agonist (pEC50values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARαrespectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Retinoic acid receptor-β
Product Description

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.

Associated Targets(Human)

RARB Tclin Retinoic acid receptor beta (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RARA Tclin Retinoic acid receptor alpha (1324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RARG Tclin Retinoic acid receptor gamma (1154 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RARB Tclin Retinoic acid receptor beta (1232 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-(4-octylphenyl)benzoic acid
INCHI InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23)
InChi Key HXBKPYIEQLLNBK-UHFFFAOYSA-N
Canonical SMILES CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O
Isomeric SMILES CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O
PubChem CID 1714884
Molecular Weight 310.44

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
A2426201Certificate of AnalysisNov 27, 2023 A288323
A2426202Certificate of AnalysisNov 27, 2023 A288323
A2426203Certificate of AnalysisNov 27, 2023 A288323
A2426204Certificate of AnalysisNov 27, 2023 A288323
A2426205Certificate of AnalysisNov 27, 2023 A288323
A2426211Certificate of AnalysisNov 27, 2023 A288323
A2426235Certificate of AnalysisNov 27, 2023 A288323
A2426236Certificate of AnalysisNov 27, 2023 A288323
A2426238Certificate of AnalysisNov 27, 2023 A288323
A2426239Certificate of AnalysisNov 27, 2023 A288323

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 31.04, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.76, Max Conc. mM: 25

Related Documents

References

1. Lund BW, Knapp AE, Piu F, Gauthier NK, Begtrup M, Hacksell U, Olsson R.  (2009)  Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands..  J Med Chem,  52  (6): (1540-5).  [PMID:19239230]

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