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AC 55649 - 97%, high purity , CAS No.59662-49-6, Agonist of Retinoic acid receptor-β

  • Moligand™
  • ≥97%
Item Number
A288323
Grouped product items
SKUSizeAvailabilityPrice Qty
A288323-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$106.90
A288323-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$96.90
A288323-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$400.90
A288323-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$346.90
A288323-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,297.90

Selective RARβ2 agonist

Basic Description

Synonyms59662-49-6|AC-55649|4-(4-octylphenyl)benzoic acid|AC 55649|AC55649|4'-n-octylbiphenyl-4-carboxylic acid|4'-octyl-[1,1'-Biphenyl]-4-carboxylic acid|4-N-Octylbiphenyl-4'-carboxylic acid|4'-octyl-4-biphenylcarboxylic acid|4'-Octylbiphenyl-4-carboxylic acid|C
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPotent, isoform-selective RARβ2 receptor agonist (pEC50values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARαrespectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of Retinoic acid receptor-β
Product Description

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARG Tclin Retinoic acid receptor gamma 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARB Tclin Retinoic acid receptor beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RARA Tclin Retinoic acid receptor alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MTOR Tclin Serine/threonine-protein kinase mTOR 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-(4-octylphenyl)benzoic acid
INCHI InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23)
InChi Key HXBKPYIEQLLNBK-UHFFFAOYSA-N
Canonical SMILES CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O
Isomeric SMILES CCCCCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O
PubChem CID 1714884
Molecular Weight 310.44

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
A2426201Certificate of AnalysisNov 27, 2023 A288323
A2426202Certificate of AnalysisNov 27, 2023 A288323
A2426203Certificate of AnalysisNov 27, 2023 A288323
A2426204Certificate of AnalysisNov 27, 2023 A288323
A2426205Certificate of AnalysisNov 27, 2023 A288323
A2426211Certificate of AnalysisNov 27, 2023 A288323
A2426235Certificate of AnalysisNov 27, 2023 A288323
A2426236Certificate of AnalysisNov 27, 2023 A288323
A2426238Certificate of AnalysisNov 27, 2023 A288323
A2426239Certificate of AnalysisNov 27, 2023 A288323

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 31.04, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.76, Max Conc. mM: 25

Related Documents

References

1. Lund BW, Knapp AE, Piu F, Gauthier NK, Begtrup M, Hacksell U, Olsson R.  (2009)  Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands..  J Med Chem,  52  (6): (1540-5).  [PMID:19239230]

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