Ac2-26 TFA salt, CAS No.151988-33-9(free), Agonist of FPR1;Agonist of FPR2/ALX;Agonist of FPR3

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    Item Number
    A288593
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    A288593-5mg
    5mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $120.90
    A288593-10mg
    10mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $190.90
    A288593-25mg
    25mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $380.90
    A288593-50mg
    50mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $600.90

    Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation

    Basic Description

    Product NameAc2-26 TFA salt, CAS No.151988-33-9(free)
    GradeMoligand™
    Product Description

    Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue。

    Specifications & PurityMoligand™, ≥95%
    Biochemical and Physiological MechanismsAnnexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, promotes detachment of neutrophils from activated mesenteric endothelium and accelerates epithelial wound repair after induced colonic inju
    SequenceAMVSEFLKQAWFIENEEQEYVQTVK(Modifications: Ala-1 = N-terminal Ac)
    Action TypeAGONIST
    Mechanism of actionAgonist of FPR1;Agonist of FPR2/ALX;Agonist of FPR3

    Associated Targets(Human)

    FPR1 Tchem fMet-Leu-Phe receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    FPR2 Tchem N-formyl peptide receptor 2 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    FPR3 Tchem N-formyl peptide receptor 3 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempProtected from light,Store at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS151988-33-9(free)

    Certificates

    Certificate of Analysis(COA)

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    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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