Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
Product Description
Information
Acelarin (NUC-1031) Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.
Targets
DNA synthesis (Cell-free assay) 0.2 nM(EC50)
In vitro
NUC-1031 is a gemcitabine phosphoramidate prodrug with potent cytostatic activity in a range of different tumor cell lines. Importantly, compared with gemcitabine, NUC-1031 activation is significantly less dependent on deoxycytidine kinase and on nucleoside transporters, and it is resistant to cytidine deaminase-mediated degradation.
In vivo
NUC-1031 shows a significant reduction in tumor volumes in vivo in pancreatic cancer xenografts.
Cell Research(from reference)
Cell lines：Murine leukemia L1210, human lymphocyte CEM
