Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | ACETONITRILE|Cyanomethane|Methyl cyanide|75-05-8|Ethanenitrile|Ethyl nitrile|Methanecarbonitrile|Methane, cyano-|Acetonitril|Cyanure de methyl|Methylkyanid|MeCN|USAF EK-488|RCRA waste number U003|Methylkyanid [Czech]|NCI-C60822|NCMe|Cyanure de methyl [Fre |
|---|---|
| Specifications & Purity | UltraPureChrom™, for MS, for UHPLC |
| Grade | for MS, for UHPLC, UltraPureChrom™ |
| Note | 卖完停产，不再备货 |
| Product Description | Acetonitrile, an aliphatic nitrile, is a highly volatile, aprotic polar organic solvent that finds wide use in analytical determinations. It is UV-transparent − a property that facilitates its utilization in spectrophotometric and fluorimetric analyses. Its low viscosity, high elution strength and miscibility in water makes it viable in many chromatography systems. Its other applications include its use as a mobile phase additive and as an extraction solvent in liquid-liquid extraction (LLC), solid-phase extraction (SPE) and microextraction for chromatographic applications, etc. Application Acetonitrile, an organic solvent, is used as a mobile phase/extraction solvent in the ultra-high performance liquid chromatorgraphy − tandem mass spectrometry (UHPLC-MS) analysis of pesticides in tobacco samples. It can be potentially used with a reverse-phase column to determine the concentration of diclofenac (DCF). Acetonitrile may be used: As an extraction solvent for the quantification of pesticide analytes in foodstuffs and tea, industrial dyes in juice and wine by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). As an organic modifier in the determination of bisphenol A-diglycidyl ether, bisphenol F-diglycidyl ether and their derivatives in canned food and beverages by fast LC–MS/MS. |
Associated Targets
NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 0 Activities
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Names and Identifiers
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F2301115 | Certificate of Analysis | May 24, 2023 | A433531 |
| F2301136 | Certificate of Analysis | May 24, 2023 | A433531 |
| F2301143 | Certificate of Analysis | May 24, 2023 | A433531 |
| F2301144 | Certificate of Analysis | May 24, 2023 | A433531 |
| F2301145 | Certificate of Analysis | May 24, 2023 | A433531 |
Chemical and Physical Properties
| Refractive Index | 1.343-1.345 |
|---|---|
| Flash Point(°C) | 2 °C |
| Boil Point(°C) | 81-82°C |
| Melt Point(°C) | -46°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07, GHS02 |
|---|---|
| Signal | Danger |
| Hazard Statements | H319:Causes serious eye irritation H302:Harmful if swallowed H225:Highly Flammable liquid and vapor H312:Harmful in contact with skin H332:Harmful if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P370+P378:In case of fire: Use ... to extinguish. P210:Keep away from heat, hot surface, sparks, open flames and other ignition sources. - No smoking. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P264:Wash hands [and …] thoroughly after handling. P403+P235:Store in a well-ventilated place. Keep cool. P303+P361+P353:IF ON SKIN (or hair): Take off Immediately all contaminated clothing. Rinse SKIN with water [or shower]. P271:Use only outdoors or in a well-ventilated area. P241:Use explosion-proof [electrical/ventilating/lighting/.../] equipment. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. |
| WGK Germany | 2 |
| Class | 3 |
| Merck Index | 70 |
Related Documents
References
| 1. P K Zarzycki,M B Zarzycka,M M Slaczka,V L Clifton. (2010-04-13) Acetonitrile, the polarity chameleon.. Analytical and bioanalytical chemistry, 397 ((3)): (905-908). [PMID:20383697] |
| 2. Barbara Giroud,Antoine Vauchez,Emmanuelle Vulliet,Laure Wiest,Audrey Buleté. (2013-10-15) Trace level determination of pyrethroid and neonicotinoid insecticides in beebread using acetonitrile-based extraction followed by analysis with ultra-high-performance liquid chromatography-tandem mass spectrometry.. Journal of chromatography. A, 1316 (53-61). [PMID:24120025] |
| 3. Gabrieli Bernardi,Magali Kemmerich,Lucila C Ribeiro,Martha B Adaime,Renato Zanella,Osmar D Prestes. (2016-10-23) An effective method for pesticide residues determination in tobacco by GC-MS/MS and UHPLC-MS/MS employing acetonitrile extraction with low-temperature precipitation and d-SPE clean-up.. Talanta, 161 (40-47). [PMID:27769424] |
| 4. Aswin Anand Pai,Anup J Devasia,John Carl Panetta,Sathya Mani,Raveen Stephen Stallon Illangeswaran,Ezhilpavai Mohanan,Balaji Balakrishnan,Kavitha M Lakshmi,Uday Kulkarni,Fouzia N Aboobacker,Anu Korula,Aby Abraham,Alok Srivastava,Vikram Mathews,Biju George,Poonkuzhali Balasubramanian. (2019-12-04) Pharmacokinetics and Efficacy of Generic Melphalan Is Comparable to Innovator Formulation in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.. Clinical lymphoma, myeloma & leukemia, 20 ((2)): (130-135). [PMID:31791694] |
| 5. Philip R Lindstedt,Francesco A Aprile,Pietro Sormanni,Robertinah Rakoto,Christopher M Dobson,Gonçalo J L Bernardes,Michele Vendruscolo. (2020-11-21) Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis.. Cell chemical biology, 28 ((1)): (70-77). [PMID:33217338] |
| 6. H Gallart-Ayala,E Moyano,M T Galceran. (2011-02-22) Fast liquid chromatography-tandem mass spectrometry for the analysis of bisphenol A-diglycidyl ether, bisphenol F-diglycidyl ether and their derivatives in canned food and beverages.. Journal of chromatography. A, 1218 ((12)): (1603-1610). [PMID:21333297] |
| 7. Roberto Nisticò,Alessandra Bianco Prevot,Giuliana Magnacca,Lorenzo Canone,Sara García-Ballesteros,Antonio Arques. (2019-08-02) Sustainable Magnetic Materials (from Chitosan and Municipal Biowaste) for the Removal of Diclofenac from Water.. Nanomaterials (Basel, Switzerland), 9 ((8)): [PMID:31366049] |
| 8. Hua Wei, Jian Liu, Xin Wang , Zihan Li , Lijuan Ju , Boxuan Yao, Jiarui Zhou, Lei Zhao, Mingyang Zhou, Jie Zhang , Shenghong Yang. (2023) Secondary metal doped cuprous-cyanoimidazole frameworks for triple-mode detection of dopamine . Secondary metal doped cuprous-cyanoimidazole frameworks for triple-mode detection of dopamine , 1279 (-): (341798). [PMID:] |
| 9. 朱立斌，徐飞，李博 ，牛广财，张彦军. (2021) 酶法提取刺五加干果花色苷工艺优化及其组成分析. 食品安全质量检测学报, 12 (17): (7006-7013). [PMID:] |